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Dph2 Gene Detail
Summary
  • Symbol
    Dph2
  • Name
    DPH2 homolog
  • Synonyms
    9130020C19Rik, Dph2l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914978
    NCBI Gene: 67728
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117745838-117749220 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914978
 protein coding gene Chr4:117745838-117749229 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028659
 protein coding gene Chr4:118893050-118896439 (-)
A/J MGP_AJ_G0028620
 protein coding gene Chr4:114305950-114309339 (-)
AKR/J MGP_AKRJ_G0028570
 protein coding gene Chr4:116812763-116816147 (-)
BALB/cJ MGP_BALBcJ_G0028641
 protein coding gene Chr4:114944688-114948078 (-)
C3H/HeJ MGP_C3HHeJ_G0028355
 protein coding gene Chr4:118387778-118391168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029082
 protein coding gene Chr4:123471298-123474687 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026366
 protein coding gene Chr4:108334835-108338249 (-)
CAST/EiJ MGP_CASTEiJ_G0027789
 protein coding gene Chr4:115614406-115617779 (-)
CBA/J MGP_CBAJ_G0028322
 protein coding gene Chr4:126839273-126842663 (-)
DBA/2J MGP_DBA2J_G0028470
 protein coding gene Chr4:114923756-114927145 (-)
FVB/NJ MGP_FVBNJ_G0028438
 protein coding gene Chr4:113439234-113442624 (-)
LP/J MGP_LPJ_G0028572
 protein coding gene Chr4:119080032-119083421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028465
 protein coding gene Chr4:131760351-131763735 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029119
 protein coding gene Chr4:117954860-117958249 (-)
PWK/PhJ MGP_PWKPhJ_G0027515
 protein coding gene Chr4:111744379-111747801 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027338
 protein coding gene Chr4:114271509-114274964 (-)
WSB/EiJ MGP_WSBEiJ_G0027868
 protein coding gene Chr4:117838605-117841994 (-)



Homology
more
  • Human Ortholog
    DPH2, diphthamide biosynthesis 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPH2, diphthamide biosynthesis 2
  • Synonyms
    DEDSSH2, DPH2L2
  • Links
    NCBI Gene ID: 1802
    neXtProt AC: NX_Q9BQC3
    UniProt: Q9BQC3

  • Chr Location
    1p34.1; chr1:43970000-43973369 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPH2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    1
  • cDNA Data
    48
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67728 NCBI Gene Model | MGI Sequence Detail 3383 C57BL/6J ±  kb
transcript NM_026344 RefSeq | MGI Sequence Detail 2548 C57BL/6  
polypeptide Q9CR25 UniProt | EBI | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006653 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR010014 Diphthamide synthesis DHP2
    IPR016435 Diphthamide synthesis DPH1/DPH2
    IPR042263 Diphthamide synthesis DPH1/DPH2, domain 1
    IPR042265 Diphthamide synthesis DPH1/DPH2, domain 3
  • GlyGen
    Q9CR25 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140302
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory