About   Help   FAQ
Rnls Pseudogene Detail
Summary
  • Symbol
    Rnls
  • Name
    renalase, FAD-dependent amine oxidase
  • Synonyms
    6530404N21Rik
Location &
Maps
more
  • Sequence Map
    Chr19:33115147-33369665 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 29.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915045
 polymorphic pseudogene Chr19:33115140-33369695 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025044
 protein coding gene Chr19:31826525-32088797 (-)
A/J MGP_AJ_G0025021
 protein coding gene Chr19:30239883-30495675 (-)
AKR/J MGP_AKRJ_G0024989
 protein coding gene Chr19:31282093-31558280 (-)
BALB/cJ MGP_BALBcJ_G0025020
 protein coding gene Chr19:30309653-30568703 (-)
C3H/HeJ MGP_C3HHeJ_G0024776
 protein coding gene Chr19:31285067-31548795 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025461
 protein coding gene Chr19:32706043-32962638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022880
 protein coding gene Chr19:30137458-30384733 (-)
CAST/EiJ MGP_CASTEiJ_G0024247
 protein coding gene Chr19:31202719-31466449 (-)
CBA/J MGP_CBAJ_G0024754
 protein coding gene Chr19:34224102-34510673 (-)
DBA/2J MGP_DBA2J_G0024886
 protein coding gene Chr19:30167806-30423751 (-)
FVB/NJ MGP_FVBNJ_G0024848
 protein coding gene Chr19:29982794-30236306 (-)
LP/J MGP_LPJ_G0024971
 protein coding gene Chr19:31828934-32087817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024875
 protein coding gene Chr19:34073146-34349277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025516
 protein coding gene Chr19:31348562-31611807 (-)
PWK/PhJ MGP_PWKPhJ_G0023995
 protein coding gene Chr19:29865831-30123712 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023799
 protein coding gene Chr19:30676991-30958575 (-)
WSB/EiJ MGP_WSBEiJ_G0024313
 protein coding gene Chr19:31381981-31643014 (-)



Homology
more
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
  • Synonyms
    C10orf59, RENALASE
  • Links
    NCBI Gene ID: 55328
    neXtProt AC: NX_Q5VYX0
    UniProt: Q5VYX0

  • Chr Location
    10q23.31; chr10:88171523-88584530 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RNLS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071573 Ensembl Gene Model | MGI Sequence Detail 254519 C57BL/6J ±  kb
    transcript ENSMUST00000096114 Ensembl | MGI Sequence Detail 1597 Not Applicable  
    polypeptide ENSMUSP00000093825 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory