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Plpp3 Gene Detail
Summary
  • Symbol
    Plpp3
  • Name
    phospholipid phosphatase 3
  • Synonyms
    1110003O22Rik, D4Bwg0538e, D4Bwg1535e, Lpp3, Ppap2b, PRG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915166
    NCBI Gene: 67916
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:105014544-105089961 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 49.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915166
 protein coding gene Chr4:105014544-105089964 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028515
 protein coding gene Chr4:105682996-105764812 (+)
A/J MGP_AJ_G0028478
 protein coding gene Chr4:101959870-102035656 (+)
AKR/J MGP_AKRJ_G0028425
 protein coding gene Chr4:104452374-104529429 (+)
BALB/cJ MGP_BALBcJ_G0028497
 protein coding gene Chr4:102156702-102232729 (+)
C3H/HeJ MGP_C3HHeJ_G0028211
 protein coding gene Chr4:105202436-105279156 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028937
 protein coding gene Chr4:109592601-109669281 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026228
 protein coding gene Chr4:97268689-97343669 (+)
CAST/EiJ MGP_CASTEiJ_G0027647
 protein coding gene Chr4:102967642-103145007 (+)
CBA/J MGP_CBAJ_G0028180
 protein coding gene Chr4:113080911-113160101 (+)
DBA/2J MGP_DBA2J_G0028328
 protein coding gene Chr4:101602739-101678182 (+)
FVB/NJ MGP_FVBNJ_G0028296
 protein coding gene Chr4:100443516-100518973 (+)
LP/J MGP_LPJ_G0028429
 protein coding gene Chr4:105889473-105970729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028322
 protein coding gene Chr4:118467896-118548589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028972
 protein coding gene Chr4:104685753-104762092 (+)
PWK/PhJ MGP_PWKPhJ_G0027373
 protein coding gene Chr4:99816009-99974508 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027197
 protein coding gene Chr4:102056559-102220082 (+)
WSB/EiJ MGP_WSBEiJ_G0027727
 protein coding gene Chr4:104841831-104918122 (+)



Homology
more
  • Human Ortholog
    PLPP3, phospholipid phosphatase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPP3, phospholipid phosphatase 3
  • Synonyms
    Dri42, LPP3, PAP2B, PPAP2B, VCIP
  • Links
    NCBI Gene ID: 8613
    neXtProt AC: NX_O14495
    UniProt: O14495

  • Chr Location
    1p32.2; chr1:56494761-56645301 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice do not survive past E10.5 and show defects in extraembryonic vasculogenesis and axis patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1265
  • Tissues
    292
  • cDNA Data
    130
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028517 Ensembl Gene Model | MGI Sequence Detail 75418 C57BL/6J ±  kb
    transcript ENSMUST00000064139 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000065719 Ensembl | MGI Sequence Detail 312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      cDNA 133
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-34207, MGD-MRK-35800, MGI:106513, MGI:107334, MGI:1915698, MGI:2140515
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 31
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory