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Puf60 Gene Detail
Summary
  • Symbol
    Puf60
  • Name
    poly-U binding splicing factor 60
  • Synonyms
    2410104I19Rik, 2810454F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915209
    NCBI Gene: 67959
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75942031-75952773 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.32 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915209
 protein coding gene Chr15:75942031-75954386 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021974
 protein coding gene Chr15:76122246-76133010 (-)
A/J MGP_AJ_G0021932
 protein coding gene Chr15:73354186-73364948 (-)
AKR/J MGP_AKRJ_G0021915
 protein coding gene Chr15:75340810-75351570 (-)
BALB/cJ MGP_BALBcJ_G0021941
 protein coding gene Chr15:73372902-73383664 (-)
C3H/HeJ MGP_C3HHeJ_G0021713
 protein coding gene Chr15:75395677-75406439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022381
 protein coding gene Chr15:78962405-78973167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019910
 protein coding gene Chr15:70020726-70031743 (-)
CAST/EiJ MGP_CASTEiJ_G0021232
 protein coding gene Chr15:76181275-76192459 (-)
CBA/J MGP_CBAJ_G0021680
 protein coding gene Chr15:81477680-81488442 (-)
DBA/2J MGP_DBA2J_G0021805
 protein coding gene Chr15:72883517-72894279 (-)
FVB/NJ MGP_FVBNJ_G0021786
 protein coding gene Chr15:71935734-71946496 (-)
LP/J MGP_LPJ_G0021876
 protein coding gene Chr15:76215003-76225764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021810
 protein coding gene Chr15:86779446-86790205 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022401
 protein coding gene Chr15:75589328-75600090 (-)
PWK/PhJ MGP_PWKPhJ_G0020973
 protein coding gene Chr15:73031142-73042314 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020812
 protein coding gene Chr15:75309453-75320500 (-)
WSB/EiJ MGP_WSBEiJ_G0021284
 protein coding gene Chr15:75673304-75684063 (-)



Homology
more
  • Human Ortholog
    PUF60, poly(U) binding splicing factor 60
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PUF60, poly(U) binding splicing factor 60
  • Synonyms
    FIR, RoBPI, SIAHBP1, VRJS
  • Links
    NCBI Gene ID: 22827
    neXtProt AC: NX_Q9UHX1
    UniProt: Q9UHX1

  • Chr Location
    8q24.3; chr8:143816344-143830709 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E4.5. Mice heterozygous for a null allele exhibit with increased organ or bone marrow invasion with poor prognosis in the presence of a Trp53 null allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002524 Ensembl Gene Model | MGI Sequence Detail 10743 C57BL/6J ±  kb
    transcript ENSMUST00000100527 Ensembl | MGI Sequence Detail 1881 Not Applicable  
    polypeptide ENSMUSP00000098096 Ensembl | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013491 poly(U)-binding-splicing factor PUF60
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR006532 Poly-U binding splicing factor, PUF60-like
      IPR051974 Poly(U)-binding-splicing regulator
      IPR034209 PUF60, RNA recognition motif 1
      IPR034211 PUF60, RNA recognition motif 2
      IPR034212 PUF60, RNA recognition motif 3
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryote
    • GlyGen
      Q3UEB3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920052
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory