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Wls Gene Detail
Summary
  • Symbol
    Wls
  • Name
    wntless WNT ligand secretion mediator
  • Synonyms
    5031439A09Rik, Gpr177
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915401
    NCBI Gene: 68151
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:159545309-159644300 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 82.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915401
 protein coding gene Chr3:159545287-159644302 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028020
 protein coding gene Chr3:163959337-164071488 (+)
A/J MGP_AJ_G0027978
 protein coding gene Chr3:158075503-158175615 (+)
AKR/J MGP_AKRJ_G0027944
 protein coding gene Chr3:162247950-162353239 (+)
BALB/cJ MGP_BALBcJ_G0027990
 protein coding gene Chr3:157865671-157965329 (+)
C3H/HeJ MGP_C3HHeJ_G0027720
 protein coding gene Chr3:162615907-162714237 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028433
 protein coding gene Chr3:169348921-169454513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025772
 protein coding gene Chr3:152467486-152567962 (+)
CAST/EiJ MGP_CASTEiJ_G0027173
 protein coding gene Chr3:162717390-162822682 (+)
CBA/J MGP_CBAJ_G0027695
 protein coding gene Chr3:175344554-175453325 (+)
DBA/2J MGP_DBA2J_G0027835
 protein coding gene Chr3:157090597-157189940 (+)
FVB/NJ MGP_FVBNJ_G0027802
 protein coding gene Chr3:154418731-154523580 (+)
LP/J MGP_LPJ_G0027946
 protein coding gene Chr3:165346389-165490563 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027835
 protein coding gene Chr3:184193886-184312591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028492
 protein coding gene Chr3:161878367-161982936 (+)
PWK/PhJ MGP_PWKPhJ_G0026896
 protein coding gene Chr3:156987314-157090613 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026724
 protein coding gene Chr3:160106951-160222255 (+)
WSB/EiJ MGP_WSBEiJ_G0027253
 protein coding gene Chr3:162841822-162945506 (+)



Homology
more
  • Human Ortholog
    WLS, Wnt ligand secretion mediator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WLS, Wnt ligand secretion mediator
  • Synonyms
    C1orf139, EVI, GPR177, mig-14, MRP, ZKS
  • Links
    NCBI Gene ID: 79971
    neXtProt AC: NX_Q5T9L3
    UniProt: Q5T9L3

  • Chr Location
    1p31.3; chr1:68098459-68233120 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wls mouse models; 1 with human WLS associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 9 alleles in 13 genetic backgrounds
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles exhibit impaired body axis and triploblastic development dying prior to E10.5. Mice homozygous for a floxed allele activated in keratinocytes exhibit a psoriasiform dermatitis-like phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1039
  • Tissues
    163
  • cDNA Data
    256
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028173 Ensembl Gene Model | MGI Sequence Detail 98992 C57BL/6J ±  kb
    transcript ENSMUST00000198878 Ensembl | MGI Sequence Detail 2050 Not Applicable  
    polypeptide ENSMUSP00000143475 Ensembl | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 265
      cDNA 256
      Primer pair 4
      Other 5

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2139641, MGI:2139844
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 48
      Diseases 1
      Gene Ontology 10
      Phenotypes 114
    • Earliest
      J:30814 Neophytou PI, et al., A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes. 1996 Feb;45(2):127-33
    • Latest
      J:350324 Polsani N, et al., Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. Development. 2024 Jun 15;151(12):dev202596
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory