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Ift80 Gene Detail
Summary
  • Symbol
    Ift80
  • Name
    intraflagellar transport 80
  • Synonyms
    4921524P20Rik, Wdr56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915509
    NCBI Gene: 68259
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68799832-68911892 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.07 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915509
 protein coding gene Chr3:68799832-68911939 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027290
 protein coding gene Chr3:68113580-68225607 (-)
A/J MGP_AJ_G0027252
 protein coding gene Chr3:66086581-66190269 (-)
AKR/J MGP_AKRJ_G0027220
 protein coding gene Chr3:67498935-67607938 (-)
BALB/cJ MGP_BALBcJ_G0027263
 protein coding gene Chr3:65960255-66067445 (-)
C3H/HeJ MGP_C3HHeJ_G0027007
 protein coding gene Chr3:67744854-67848588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027709
 protein coding gene Chr3:70650673-70776278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025062
 protein coding gene Chr3:62353013-62456105 (-)
CAST/EiJ MGP_CASTEiJ_G0026454
 protein coding gene Chr3:67692249-67800780 (-)
CBA/J MGP_CBAJ_G0026982
 protein coding gene Chr3:72846741-72960928 (-)
DBA/2J MGP_DBA2J_G0027118
 protein coding gene Chr3:65589890-65697619 (-)
FVB/NJ MGP_FVBNJ_G0027086
 protein coding gene Chr3:64214858-64319395 (-)
LP/J MGP_LPJ_G0027226
 protein coding gene Chr3:69051988-69162466 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027105
 protein coding gene Chr3:77461096-77576524 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027767
 protein coding gene Chr3:67385889-67498366 (-)
PWK/PhJ MGP_PWKPhJ_G0026188
 protein coding gene Chr3:65317994-65423524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026004
 protein coding gene Chr3:66491098-66603056 (-)
WSB/EiJ MGP_WSBEiJ_G0026532
 protein coding gene Chr3:67524376-67654338 (-)



Homology
more
  • Human Ortholog
    IFT80, intraflagellar transport 80
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT80, intraflagellar transport 80
  • Synonyms
    ATD2, CFAP167, FAP167, SRTD2, WDR56
  • Links
    NCBI Gene ID: 57560
    neXtProt AC: NX_Q9P2H3
    UniProt: Q9P2H3

  • Chr Location
    3q25.33; chr3:160256986-160399880 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ift80 mouse models; 1 with human IFT80 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele exhibit partial perinatal lethality, decreased body size, postnatal growth retardation, shortened long bones, constricted thoracic cage, periaxial polydactyly, and small cranium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    12
  • cDNA Data
    66
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027778 Ensembl Gene Model | MGI Sequence Detail 112061 C57BL/6J ±  kb
    transcript ENSMUST00000107812 Ensembl | MGI Sequence Detail 4063 Not Applicable  
    polypeptide ENSMUSP00000103442 Ensembl | MGI Sequence Detail 777 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 22
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory