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Ints1 Gene Detail
Summary
  • Symbol
    Ints1
  • Name
    integrator complex subunit 1
  • Synonyms
    1110015K06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915760
    NCBI Gene: 68510
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139737037-139761429 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.80 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    841 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915760
 protein coding gene Chr5:139737037-139761455 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030289
 protein coding gene Chr5:144765357-144789799 (-)
A/J MGP_AJ_G0030258
 protein coding gene Chr5:138617835-138642136 (-)
AKR/J MGP_AKRJ_G0030190
 protein coding gene Chr5:142945394-142969746 (-)
BALB/cJ MGP_BALBcJ_G0030275
 protein coding gene Chr5:139859939-139884499 (-)
C3H/HeJ MGP_C3HHeJ_G0029986
 protein coding gene Chr5:143718121-143742471 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030720
 protein coding gene Chr5:150108552-150132797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027938
 protein coding gene Chr5:132473888-132497621 (-)
CAST/EiJ MGP_CASTEiJ_G0029391
 protein coding gene Chr5:143133041-143157643 (-)
CBA/J MGP_CBAJ_G0029956
 protein coding gene Chr5:156307970-156332147 (-)
DBA/2J MGP_DBA2J_G0030106
 protein coding gene Chr5:138429147-138453704 (-)
FVB/NJ MGP_FVBNJ_G0030061
 protein coding gene Chr5:137548776-137580647 (-)
LP/J MGP_LPJ_G0030192
 protein coding gene Chr5:145379477-145403808 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030092
 protein coding gene Chr5:158919460-158951308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030760
 protein coding gene Chr5:142775810-142800151 (-)
PWK/PhJ MGP_PWKPhJ_G0029106
 protein coding gene Chr5:137444250-137469940 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028942
 protein coding gene Chr5:140452101-140476946 (-)
WSB/EiJ MGP_WSBEiJ_G0029465
 protein coding gene Chr5:143534926-143560788 (-)



Homology
more
  • Human Ortholog
    INTS1, integrator complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS1, integrator complex subunit 1
  • Synonyms
    INT1, NDCAGF, NET28
  • Links
    NCBI Gene ID: 26173
    neXtProt AC: NX_Q8N201
    UniProt: Q8N201

  • Chr Location
    7p22.3; chr7:1470277-1504389 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human INTS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality at the blastocyst stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    138
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029547 Ensembl Gene Model | MGI Sequence Detail 24393 C57BL/6J ±  kb
transcript ENSMUST00000200393 Ensembl | MGI Sequence Detail 7070 Not Applicable  
polypeptide ENSMUSP00000143789 Ensembl | MGI Sequence Detail 2195 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009066 integrator complex subunit 1
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR038902 Integrator complex subunit 1
    IPR022145 Integrator complex subunit 1, RPB2-binding domain
  • GlyGen
    Q6P4S8 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 139
    cDNA 138
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory