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Prickle1 Gene Detail
Summary
  • Symbol
    Prickle1
  • Name
    prickle planar cell polarity protein 1
  • Synonyms
    1110058P22Rik, b2b019Clo, mpk1, Pk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916034
    NCBI Gene: 106042
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:93396995-93493772 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 47.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2720 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916034
 protein coding gene Chr15:93396992-93494147 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022257
 protein coding gene Chr15:94923986-95032933 (-)
A/J MGP_AJ_G0022216
 protein coding gene Chr15:91252818-91351027 (-)
AKR/J MGP_AKRJ_G0022191
 protein coding gene Chr15:93976107-94082712 (-)
BALB/cJ MGP_BALBcJ_G0022222
 protein coding gene Chr15:91369441-91475636 (-)
C3H/HeJ MGP_C3HHeJ_G0021992
 protein coding gene Chr15:93989451-94095904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022667
 protein coding gene Chr15:98394093-98505998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020193
 protein coding gene Chr15:87294082-87388391 (-)
CAST/EiJ MGP_CASTEiJ_G0021514
 protein coding gene Chr15:94808356-94912982 (-)
CBA/J MGP_CBAJ_G0021959
 protein coding gene Chr15:101715427-101831481 (-)
DBA/2J MGP_DBA2J_G0022086
 protein coding gene Chr15:90677821-90777470 (-)
FVB/NJ MGP_FVBNJ_G0022065
 protein coding gene Chr15:89695125-89792529 (-)
LP/J MGP_LPJ_G0022157
 protein coding gene Chr15:95026849-95129949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022085
 protein coding gene Chr15:106054868-106160722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022682
 protein coding gene Chr15:94062774-94170329 (-)
PWK/PhJ MGP_PWKPhJ_G0021255
 protein coding gene Chr15:90728571-90829604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021089
 protein coding gene Chr15:93796616-93900205 (-)
WSB/EiJ MGP_WSBEiJ_G0021563
 protein coding gene Chr15:94550639-94664216 (-)



Homology
more
  • Human Ortholog
    PRICKLE1, prickle planar cell polarity protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRICKLE1, prickle planar cell polarity protein 1
  • Synonyms
    EPM1B, RILP
  • Links
    NCBI Gene ID: 144165
    neXtProt AC: NX_Q96MT3
    UniProt: Q96MT3

  • Chr Location
    12q12; chr12:42456757-42590355 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Prickle1 mouse models; 1 with human PRICKLE1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 8 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous null or point mutations result in decreased seizure threshold. Homozygous null mice display early embryonic lethality associated with altered epiblast apical-basal polarity, failed anterior migration of the distal visceral endoderm, and lackof mesoderm and primitive streak formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    108
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1107
  • Tissues
    206
  • cDNA Data
    18
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036158 Ensembl Gene Model | MGI Sequence Detail 96778 C57BL/6J ±  kb
    transcript ENSMUST00000048982 Ensembl | MGI Sequence Detail 4085 Not Applicable  
    polypeptide ENSMUSP00000049204 Ensembl | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 18
      Primer pair 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2146210, MGI:5300247
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 44
      Diseases 4
      Gene Ontology 22
      Phenotypes 47
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:344941 Yan F, et al., Single-cell multiomics decodes regulatory programs for mouse secondary palate development. Nat Commun. 2024 Jan 27;15(1):821
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory