About   Help   FAQ
Zfand2b Gene Detail
Summary
  • Symbol
    Zfand2b
  • Name
    zinc finger, AN1 type domain 2B
  • Synonyms
    1110060O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916068
    NCBI Gene: 68818
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75145290-75148270 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.61 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916068
 protein coding gene Chr1:75145290-75148273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016173
 protein coding gene Chr1:75730887-75733870 (+)
A/J MGP_AJ_G0016156
 protein coding gene Chr1:73090434-73093415 (+)
AKR/J MGP_AKRJ_G0016113
 protein coding gene Chr1:75119418-75122399 (+)
BALB/cJ MGP_BALBcJ_G0016111
 protein coding gene Chr1:73152438-73155421 (+)
C3H/HeJ MGP_C3HHeJ_G0015942
 protein coding gene Chr1:75450014-75452995 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016564
 protein coding gene Chr1:78681396-78684379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014285
 protein coding gene Chr1:68651187-68654279 (+)
CAST/EiJ MGP_CASTEiJ_G0015526
 protein coding gene Chr1:74786675-74789651 (+)
CBA/J MGP_CBAJ_G0015915
 protein coding gene Chr1:81239611-81242592 (+)
DBA/2J MGP_DBA2J_G0016016
 protein coding gene Chr1:72409346-72412329 (+)
FVB/NJ MGP_FVBNJ_G0016019
 protein coding gene Chr1:71607608-71610591 (+)
LP/J MGP_LPJ_G0016088
 protein coding gene Chr1:76854813-76857796 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016039
 protein coding gene Chr1:84597845-84600826 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016611
 protein coding gene Chr1:75189250-75192233 (+)
PWK/PhJ MGP_PWKPhJ_G0015313
 protein coding gene Chr1:71878923-71881895 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015091
 protein coding gene Chr1:74549729-74552683 (+)
WSB/EiJ MGP_WSBEiJ_G0015588
 protein coding gene Chr1:75000507-75003490 (+)



Homology
more
  • Human Ortholog
    ZFAND2B, zinc finger AN1-type containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFAND2B, zinc finger AN1-type containing 2B
  • Synonyms
    AIRAPL
  • Links
    NCBI Gene ID: 130617
    neXtProt AC: NX_Q8WV99
    UniProt: Q8WV99

  • Chr Location
    2q35; chr2:219195237-219209651 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prematurely due to a myeloproliferative disorder characterized by splenomegaly, increased WBC and platelet count, increased hematocrit, reduced long-term hematopoietic stem cells (HSCs) in bone marrow and spleen, and increased LSK+ and progenitor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68818 NCBI Gene Model | MGI Sequence Detail 2981 C57BL/6J ±  kb
    transcript NM_026846 RefSeq | MGI Sequence Detail 1240 C57BL/6  
    polypeptide Q91X58 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138701
    References
    more
    • Summaries
      All 51
      Diseases 1
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261061 Rahighi S, et al., Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. Structure. 2016 Mar 1;24(3):412-22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory