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Chst8 Gene Detail
Summary
  • Symbol
    Chst8
  • Name
    carbohydrate sulfotransferase 8
  • Synonyms
    1500011J21Rik, GalNAc4ST-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916197
    NCBI Gene: 68947
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34373893-34512136 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 20.53 cM, cytoband B3-B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916197
 protein coding gene Chr7:34373893-34512136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032079
 protein coding gene Chr7:33994824-34152753 (-)
A/J MGP_AJ_G0032059
 protein coding gene Chr7:33109971-33253535 (-)
AKR/J MGP_AKRJ_G0031992
 protein coding gene Chr7:33901260-34053755 (-)
BALB/cJ MGP_BALBcJ_G0032066
 protein coding gene Chr7:33413287-33554875 (-)
C3H/HeJ MGP_C3HHeJ_G0031783
 protein coding gene Chr7:34802837-34947659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032543
 protein coding gene Chr7:35690816-35848228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029576
 protein coding gene Chr7:33841966-33981780 (-)
CAST/EiJ MGP_CASTEiJ_G0031118
 protein coding gene Chr7:25919131-26079220 (-)
CBA/J MGP_CBAJ_G0031751
 protein coding gene Chr7:36801879-36970309 (-)
DBA/2J MGP_DBA2J_G0031903
 protein coding gene Chr7:32960625-33101756 (-)
FVB/NJ MGP_FVBNJ_G0031858
 protein coding gene Chr7:32884216-33028028 (-)
LP/J MGP_LPJ_G0031980
 protein coding gene Chr7:34330756-34483112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031896
 protein coding gene Chr7:35851884-36007203 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032558
 protein coding gene Chr7:33439002-33588560 (-)
PWK/PhJ MGP_PWKPhJ_G0030840
 protein coding gene Chr7:26286927-26431114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030675
 protein coding gene Chr7:23006127-23163930 (-)
WSB/EiJ MGP_WSBEiJ_G0031228
 protein coding gene Chr7:33978952-34141229 (-)



Homology
more
  • Human Ortholog
    CHST8, carbohydrate sulfotransferase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST8, carbohydrate sulfotransferase 8
  • Synonyms
    GalNAc4ST, GALNAC4ST1, PSS3
  • Links
    NCBI Gene ID: 64377
    neXtProt AC: NX_Q9H2A9
    UniProt: Q9H2A9

  • Chr Location
    19q13.11; chr19:33621953-33773509 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele show higher luteinizing hormone and testosterone levels, early sexual maturation and enlarged seminal vesicles; females show higher LH, estrogen and progesterone levels, early sexual maturation, enlarged uteri, a prolonged estrous cycle and increased fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    41
  • cDNA Data
    15
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68947 NCBI Gene Model | MGI Sequence Detail 138244 C57BL/6J ±  kb
    transcript NM_175140 RefSeq | MGI Sequence Detail 2397 C57BL/6  
    polypeptide Q8BQ86 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141936
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:66120 Xia G, et al., Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. J Biol Chem. 2000 Dec 8;275(49):38402-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory