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Gsdmd Gene Detail
Summary
  • Symbol
    Gsdmd
  • Name
    gasdermin D
  • Synonyms
    1810036L03Rik, DF5L, Dfna5l, Gsdmdc1, M2-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916396
    NCBI Gene: 69146
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75734176-75739257 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.00 cM, cytoband D3-E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916396
 protein coding gene Chr15:75733990-75739257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021960
 protein coding gene Chr15:75903465-75909624 (+)
A/J MGP_AJ_G0021918
 protein coding gene Chr15:73144409-73149533 (+)
AKR/J MGP_AKRJ_G0021901
 protein coding gene Chr15:75111734-75118392 (+)
BALB/cJ MGP_BALBcJ_G0021927
 protein coding gene Chr15:73159766-73164867 (+)
C3H/HeJ MGP_C3HHeJ_G0021699
 protein coding gene Chr15:75183397-75188466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022367
 protein coding gene Chr15:78738745-78743810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019898
 protein coding gene Chr15:69817093-69822034 (+)
CAST/EiJ MGP_CASTEiJ_G0021218
 protein coding gene Chr15:75960296-75965325 (+)
CBA/J MGP_CBAJ_G0021666
 protein coding gene Chr15:81251654-81256704 (+)
DBA/2J MGP_DBA2J_G0021791
 protein coding gene Chr15:72674414-72679483 (+)
FVB/NJ MGP_FVBNJ_G0021772
 protein coding gene Chr15:71723475-71728963 (+)
LP/J MGP_LPJ_G0021862
 protein coding gene Chr15:75990355-75995403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021796
 protein coding gene Chr15:86564363-86569425 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022387
 protein coding gene Chr15:75365528-75370586 (+)
PWK/PhJ MGP_PWKPhJ_G0020959
 protein coding gene Chr15:72809141-72814241 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020798
 protein coding gene Chr15:75096336-75101377 (+)
WSB/EiJ MGP_WSBEiJ_G0021270
 protein coding gene Chr15:75451747-75456777 (+)



Homology
more
  • Human Ortholog
    GSDMD, gasdermin D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDMD, gasdermin D
  • Synonyms
    DF5L, DFNA5L, FKSG10, GSDMDC1
  • Links
    NCBI Gene ID: 79792
    neXtProt AC: NX_P57764
    UniProt: P57764

  • Chr Location
    8q24.3; chr8:143553207-143563062 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 7 alleles in 5 genetic backgrounds
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    3
  • Endonuclease-mediated
    21
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    7
  • Genomic Mutations
    5 involving Gsdmd
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    32 strains or lines available
Mice homozygous for a knock-out allele are viable and grossly normal with no apparent defects in the development and maintenance of the intestinal epithelium. Mice homozygous for another null allele exhibit impaired induced pyroptosis and Il1b secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    40
  • cDNA Data
    37
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022575 Ensembl Gene Model | MGI Sequence Detail 5082 C57BL/6J ±  kb
transcript ENSMUST00000023238 Ensembl | MGI Sequence Detail 1792 Not Applicable  
polypeptide ENSMUSP00000023238 Ensembl | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146243
References
more
  • Summaries
    All 235
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 16
    Phenotypes 160
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:357569 Gao H, et al., Gasdermin D promotes development of intestinal tumors through regulating IL-1beta release and gut microbiota composition. Cell Commun Signal. 2024 Oct 21;22(1):511
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory