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Hopx Gene Detail
Summary
  • Symbol
    Hopx
  • Name
    HOP homeobox
  • Synonyms
    1110018K11Rik, 1200015P04Rik, 2300002F06Rik, Cameo, Hod, Hop, Ob1, Toto
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916782
    NCBI Gene: 74318
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77234835-77262968 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1043 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916782
 protein coding gene Chr5:77234831-77262970 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029654
 protein coding gene Chr5:77306818-77340608 (-)
A/J MGP_AJ_G0029622
 protein coding gene Chr5:74349283-74378146 (-)
AKR/J MGP_AKRJ_G0029570
 protein coding gene Chr5:76786889-76815868 (-)
BALB/cJ MGP_BALBcJ_G0029631
 protein coding gene Chr5:75088130-75117152 (-)
C3H/HeJ MGP_C3HHeJ_G0029354
 protein coding gene Chr5:77148887-77181027 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030085
 protein coding gene Chr5:80401750-80437564 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027326
 protein coding gene Chr5:69974313-70002579 (-)
CAST/EiJ MGP_CASTEiJ_G0028762
 protein coding gene Chr5:76366627-76399102 (-)
CBA/J MGP_CBAJ_G0029323
 protein coding gene Chr5:83047971-83086230 (-)
DBA/2J MGP_DBA2J_G0029468
 protein coding gene Chr5:74412904-74441893 (-)
FVB/NJ MGP_FVBNJ_G0029429
 protein coding gene Chr5:73612690-73641423 (-)
LP/J MGP_LPJ_G0029555
 protein coding gene Chr5:77743351-77773772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029457
 protein coding gene Chr5:86180475-86210434 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030118
 protein coding gene Chr5:76333045-76367726 (-)
PWK/PhJ MGP_PWKPhJ_G0028485
 protein coding gene Chr5:73427887-73458518 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028320
 protein coding gene Chr5:75691930-75729006 (-)
WSB/EiJ MGP_WSBEiJ_G0028842
 protein coding gene Chr5:76658691-76689241 (-)



Homology
more
  • Human Ortholog
    HOPX, HOP homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOPX, HOP homeobox
  • Synonyms
    CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO
  • Links
    NCBI Gene ID: 84525
    neXtProt AC: NX_Q9BPY8
    UniProt: Q9BPY8

  • Chr Location
    4q12; chr4:56647989-56681877 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes partial embryonic lethality due to severe developmental cardiac anomalies involving the myocardium, and leads to conduction defects in surviving adults. Mice homozygous for one null allele also exhibit impairedlung maturation leading to neonatal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1221
  • Tissues
    246
  • cDNA Data
    16
  • Literature Summary
    104
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059325 Ensembl Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
    transcript ENSMUST00000120827 Ensembl | MGI Sequence Detail 1217 Not Applicable  
    polypeptide ENSMUSP00000113295 Ensembl | MGI Sequence Detail 73 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 17
      Primer pair 10
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914646, MGI:1921568, MGI:2140984, MGI:2141197
    References
    more
    • Summaries
      All 192
      Developmental Gene Expression 104
      Gene Ontology 16
      Phenotypes 67
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory