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Vrk2 Gene Detail
Summary
  • Symbol
    Vrk2
  • Name
    vaccinia related kinase 2
  • Synonyms
    2810003O05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917172
    NCBI Gene: 69922
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:26421398-26544006 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 15.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917172
 protein coding gene Chr11:26421322-26544006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018098
 protein coding gene Chr11:24334896-24456783 (-)
A/J MGP_AJ_G0018071
 protein coding gene Chr11:23389520-23512903 (-)
AKR/J MGP_AKRJ_G0018035
 protein coding gene Chr11:24211803-24339193 (-)
BALB/cJ MGP_BALBcJ_G0018039
 protein coding gene Chr11:23531049-23649150 (-)
C3H/HeJ MGP_C3HHeJ_G0017853
 protein coding gene Chr11:24090388-24219338 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018491
 protein coding gene Chr11:25253721-25387125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016149
 protein coding gene Chr11:22188909-22306657 (-)
CAST/EiJ MGP_CASTEiJ_G0017414
 protein coding gene Chr11:24159238-24282555 (-)
CBA/J MGP_CBAJ_G0017827
 protein coding gene Chr11:26383684-26519142 (-)
DBA/2J MGP_DBA2J_G0017937
 protein coding gene Chr11:23284631-23407731 (-)
FVB/NJ MGP_FVBNJ_G0017929
 protein coding gene Chr11:23074619-23187886 (-)
LP/J MGP_LPJ_G0018008
 protein coding gene Chr11:24449703-24569277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017955
 protein coding gene Chr11:26960725-27102117 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018532
 protein coding gene Chr11:24313570-24435028 (-)
PWK/PhJ MGP_PWKPhJ_G0017195
 protein coding gene Chr11:23388044-23519130 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016992
 protein coding gene Chr11:24014786-24131010 (-)
WSB/EiJ MGP_WSBEiJ_G0017468
 protein coding gene Chr11:23956855-24083411 (-)



Homology
more
  • Human Ortholog
    VRK2, VRK serine/threonine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VRK2, VRK serine/threonine kinase 2
  • Links
    NCBI Gene ID: 7444
    neXtProt AC: NX_Q86Y07
    UniProt: Q86Y07

  • Chr Location
    2p16.1; chr2:57907592-58159920 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    48
  • cDNA Data
    7
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69922 NCBI Gene Model | MGI Sequence Detail 122609 C57BL/6J ±  kb
transcript NM_027260 RefSeq | MGI Sequence Detail 1906 C57BL/6  
polypeptide Q8BN21 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144163
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:344885 Yin MY, et al., Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. BMC Med. 2023 Jul 14;21(1):256
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory