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Ace2 Gene Detail
Summary
  • Symbol
    Ace2
  • Name
    angiotensin converting enzyme 2
  • Synonyms
    2010305L05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917258
    NCBI Gene: 70008
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162922338-162971414 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.12 cM, cytoband F5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917258
 protein coding gene ChrX:162922328-162971416 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036252
 protein coding gene ChrX:162218965-162269810 (+)
A/J MGP_AJ_G0036222
 protein coding gene ChrX:161400319-161449784 (+)
AKR/J MGP_AKRJ_G0036150
 protein coding gene ChrX:166580201-166629265 (+)
BALB/cJ MGP_BALBcJ_G0036215
 protein coding gene ChrX:159394366-159444730 (+)
C3H/HeJ MGP_C3HHeJ_G0035922
 protein coding gene ChrX:162566358-162615444 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036738
 protein coding gene ChrX:166970811-167020853 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033558
 protein coding gene ChrX:152442970-152492599 (+)
CAST/EiJ MGP_CASTEiJ_G0035210
 protein coding gene ChrX:141549779-141602828 (+)
CBA/J MGP_CBAJ_G0035896
 protein coding gene ChrX:171811367-171864387 (+)
DBA/2J MGP_DBA2J_G0036062
 protein coding gene ChrX:160280857-160331088 (+)
FVB/NJ MGP_FVBNJ_G0035994
 protein coding gene ChrX:159409984-159463154 (+)
LP/J MGP_LPJ_G0036147
 protein coding gene ChrX:163352715-163405534 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036026
 protein coding gene ChrX:180495401-180548453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036777
 protein coding gene ChrX:161703430-161755480 (+)
PWK/PhJ MGP_PWKPhJ_G0034908
 protein coding gene ChrX:138326695-138376987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034729
 protein coding gene ChrX:142048543-142101801 (+)
WSB/EiJ MGP_WSBEiJ_G0035345
 protein coding gene ChrX:159672703-159725353 (+)



Homology
more
  • Human Ortholog
    ACE2, angiotensin converting enzyme 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACE2, angiotensin converting enzyme 2
  • Synonyms
    ACEH
  • Links
    NCBI Gene ID: 59272
    neXtProt AC: NX_Q9BYF1
    UniProt: Q9BYF1

  • Chr Location
    Xp22.2; chrX:15494566-15607236 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ace2 mouse models; 8 with human ACE2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    83 phenotypes from 11 alleles in 17 genetic backgrounds
    9 phenotypes from multigenic genotypes
    187 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this locus results in reduced cardiac contractility. Male mice hemizygous for a knock-out allele exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1032
  • Tissues
    138
  • cDNA Data
    26
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70008 NCBI Gene Model | MGI Sequence Detail 49077 C57BL/6J ±  kb
    transcript NM_001130513 RefSeq | MGI Sequence Detail 3566 ZRU/MplStud  
    polypeptide Q8R0I0 UniProt | EBI | MGI Sequence Detail 805 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 26
      Primer pair 15

      Microarray probesets 5
    References
    more
    • Summaries
      All 312
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 17
      Phenotypes 187
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353855 Zhang L, et al., Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach. Exp Neurol. 2024 Aug 12;381:114921
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory