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Fuz Gene Detail
Summary
  • Symbol
    Fuz
  • Name
    fuzzy planar cell polarity protein
  • Synonyms
    2600013E07Rik, b2b1273Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917550
    NCBI Gene: 70300
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44545517-44552053 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.99 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917550
 protein coding gene Chr7:44545503-44552055 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032185
 protein coding gene Chr7:45105320-45109881 (+)
A/J MGP_AJ_G0032164
 protein coding gene Chr7:44260360-44264921 (+)
AKR/J MGP_AKRJ_G0032100
 protein coding gene Chr7:45478527-45483088 (+)
BALB/cJ MGP_BALBcJ_G0032176
 protein coding gene Chr7:44259652-44264213 (+)
C3H/HeJ MGP_C3HHeJ_G0031892
 protein coding gene Chr7:45979438-45983999 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032668
 protein coding gene Chr7:47369587-47374131 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029682
 protein coding gene Chr7:46830164-46834692 (+)
CAST/EiJ MGP_CASTEiJ_G0031220
 protein coding gene Chr7:37353894-37358442 (+)
CBA/J MGP_CBAJ_G0031856
 protein coding gene Chr7:48924862-48929423 (+)
DBA/2J MGP_DBA2J_G0032014
 protein coding gene Chr7:43930397-43934958 (+)
FVB/NJ MGP_FVBNJ_G0031965
 protein coding gene Chr7:43708323-43712867 (+)
LP/J MGP_LPJ_G0032092
 protein coding gene Chr7:45789180-45793724 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032002
 protein coding gene Chr7:47658737-47663281 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032684
 protein coding gene Chr7:44702688-44707232 (+)
PWK/PhJ MGP_PWKPhJ_G0030943
 protein coding gene Chr7:37296167-37300780 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030781
 protein coding gene Chr7:32702433-32707010 (+)
WSB/EiJ MGP_WSBEiJ_G0031337
 protein coding gene Chr7:45174858-45179419 (+)



Homology
more
  • Human Ortholog
    FUZ, fuzzy planar cell polarity protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUZ, fuzzy planar cell polarity protein
  • Synonyms
    CPLANE3, FY, NTD
  • Links
    NCBI Gene ID: 80199
    neXtProt AC: NX_Q9BT04
    UniProt: Q9BT04

  • Chr Location
    19q13.33; chr19:49806866-49817376 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FUZ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 4 alleles in 5 genetic backgrounds
    20 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit neural tube closure defects, abnormal craniofacial morphology, abnormal skeletal morphology, polydactyly, anopthalmia, pulmonary hopyplasia, and cardiac outflow tract defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70300 NCBI Gene Model | MGI Sequence Detail 6537 C57BL/6J ±  kb
    transcript NM_001403451 RefSeq | MGI Sequence Detail 2574 ZRU/MplStud  
    polypeptide Q3UYI6 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5311357
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 18
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:355695 Kim SE, et al., Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development. Development. 2024 Oct 1;151(19)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory