About   Help   FAQ
Wwtr1 Gene Detail
Summary
  • Symbol
    Wwtr1
  • Name
    WW domain containing transcription regulator 1
  • Synonyms
    2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917649
    NCBI Gene: 97064
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:57363070-57483331 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 27.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3371 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917649
 protein coding gene Chr3:57363065-57483331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027229
 protein coding gene Chr3:56245947-56370050 (-)
A/J MGP_AJ_G0027189
 protein coding gene Chr3:54494219-54617335 (-)
AKR/J MGP_AKRJ_G0027159
 protein coding gene Chr3:55627829-55751358 (-)
BALB/cJ MGP_BALBcJ_G0027202
 protein coding gene Chr3:54330060-54450965 (-)
C3H/HeJ MGP_C3HHeJ_G0026945
 protein coding gene Chr3:55822488-55944126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027648
 protein coding gene Chr3:58328682-58454060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025006
 protein coding gene Chr3:50893854-51013697 (-)
CAST/EiJ MGP_CASTEiJ_G0026397
 protein coding gene Chr3:55982588-56108692 (-)
CBA/J MGP_CBAJ_G0026921
 protein coding gene Chr3:60255057-60387447 (-)
DBA/2J MGP_DBA2J_G0027055
 protein coding gene Chr3:53996547-54123447 (-)
FVB/NJ MGP_FVBNJ_G0027023
 protein coding gene Chr3:52975011-53097747 (-)
LP/J MGP_LPJ_G0027167
 protein coding gene Chr3:56979819-57111279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027041
 protein coding gene Chr3:64357248-64480786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027706
 protein coding gene Chr3:55564093-55688711 (-)
PWK/PhJ MGP_PWKPhJ_G0026129
 protein coding gene Chr3:53648693-53772683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025942
 protein coding gene Chr3:55253542-55376007 (-)
WSB/EiJ MGP_WSBEiJ_G0026471
 protein coding gene Chr3:55654867-55774084 (-)



Homology
more
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Synonyms
    TAZ
  • Links
    NCBI Gene ID: 25937
    neXtProt AC: NX_Q9GZV5
    UniProt: Q9GZV5

  • Chr Location
    3q25.1; chr3:149517235-149736714 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wwtr1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 7 alleles in 9 genetic backgrounds
    19 phenotypes from multigenic genotypes
    6 images
    200 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    90
  • cDNA Data
    102
  • Literature Summary
    74
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027803 Ensembl Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
    transcript ENSMUST00000120977 Ensembl | MGI Sequence Detail 4533 Not Applicable  
    polypeptide ENSMUSP00000113040 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 102
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917177, MGI:2140055
    References
    more
    • Summaries
      All 329
      Developmental Gene Expression 74
      Diseases 2
      Gene Ontology 22
      Phenotypes 200
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:353282 Chen R, et al., Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling. Cell Stem Cell. 2024 Jul 18;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory