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Tspan15 Gene Detail
Summary
  • Symbol
    Tspan15
  • Name
    tetraspanin 15
  • Synonyms
    2700063A19Rik, Tm4sf15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917673
    NCBI Gene: 70423
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62021175-62067030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1563 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917673
 protein coding gene Chr10:62021175-62067055 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017293
 protein coding gene Chr10:61584928-61639795 (-)
A/J MGP_AJ_G0017271
 protein coding gene Chr10:59721653-59767996 (-)
AKR/J MGP_AKRJ_G0017231
 protein coding gene Chr10:61280690-61325952 (-)
BALB/cJ MGP_BALBcJ_G0017231
 protein coding gene Chr10:59797797-59846306 (-)
C3H/HeJ MGP_C3HHeJ_G0017054
 protein coding gene Chr10:61192623-61242820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017689
 protein coding gene Chr10:63802230-63858546 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015379
 protein coding gene Chr10:56693295-56736714 (-)
CAST/EiJ MGP_CASTEiJ_G0016625
 protein coding gene Chr10:61220755-61276242 (-)
CBA/J MGP_CBAJ_G0017026
 protein coding gene Chr10:66191816-66248810 (-)
DBA/2J MGP_DBA2J_G0017131
 protein coding gene Chr10:58991498-59038618 (-)
FVB/NJ MGP_FVBNJ_G0017125
 protein coding gene Chr10:58251748-58298945 (-)
LP/J MGP_LPJ_G0017205
 protein coding gene Chr10:61979623-62031572 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017153
 protein coding gene Chr10:68429196-68482712 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017727
 protein coding gene Chr10:61111110-61158967 (-)
PWK/PhJ MGP_PWKPhJ_G0016408
 protein coding gene Chr10:58849008-58895303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016190
 protein coding gene Chr10:60483972-60538897 (-)
WSB/EiJ MGP_WSBEiJ_G0016689
 protein coding gene Chr10:61033919-61088127 (-)



Homology
more
  • Human Ortholog
    TSPAN15, tetraspanin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN15, tetraspanin 15
  • Synonyms
    2700063A19Rik, NET-7, NET7, TM4SF15
  • Links
    NCBI Gene ID: 23555
    neXtProt AC: NX_O95858
    UniProt: O95858

  • Chr Location
    10q22.1; chr10:69451465-69549508 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight increase in mortality within the first 3 weeks of birth. No overt neurological symptoms or hippocampal synapse abnormalities are seen. A different knock-out allele showed incomplete preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    44
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037031 Ensembl Gene Model | MGI Sequence Detail 45856 C57BL/6J ±  kb
    transcript ENSMUST00000047883 Ensembl | MGI Sequence Detail 3638 Not Applicable  
    polypeptide ENSMUSP00000047029 Ensembl | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915962, MGI:2143799
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory