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Arhgef26 Gene Detail
Summary
  • Symbol
    Arhgef26
  • Name
    Rho guanine nucleotide exchange factor 26
  • Synonyms
    4631416L12Rik, 8430436L14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918053
    NCBI Gene: 622434
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:62245765-62369642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918053
 protein coding gene Chr3:62244946-62369642 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027258
 protein coding gene Chr3:61305907-61440653 (+)
A/J MGP_AJ_G0027218
 protein coding gene Chr3:59536686-59655818 (+)
AKR/J MGP_AKRJ_G0027188
 protein coding gene Chr3:60686192-60806899 (+)
BALB/cJ MGP_BALBcJ_G0027231
 protein coding gene Chr3:59276905-59398613 (+)
C3H/HeJ MGP_C3HHeJ_G0026974
 protein coding gene Chr3:60877276-60998857 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027677
 protein coding gene Chr3:63610405-63733369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025031
 protein coding gene Chr3:56061451-56171583 (+)
CAST/EiJ MGP_CASTEiJ_G0026426
 protein coding gene Chr3:61066241-61183763 (+)
CBA/J MGP_CBAJ_G0026950
 protein coding gene Chr3:65654085-65789389 (+)
DBA/2J MGP_DBA2J_G0027084
 protein coding gene Chr3:58917408-59038856 (+)
FVB/NJ MGP_FVBNJ_G0027052
 protein coding gene Chr3:57762653-57877806 (+)
LP/J MGP_LPJ_G0027195
 protein coding gene Chr3:62169173-62302888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027069
 protein coding gene Chr3:70076721-70205967 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027735
 protein coding gene Chr3:60592111-60716679 (+)
PWK/PhJ MGP_PWKPhJ_G0026158
 protein coding gene Chr3:58541622-58658442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025971
 protein coding gene Chr3:60137080-60256529 (+)
WSB/EiJ MGP_WSBEiJ_G0026500
 protein coding gene Chr3:60741892-60862504 (+)



Homology
more
  • Human Ortholog
    ARHGEF26, Rho guanine nucleotide exchange factor 26
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF26, Rho guanine nucleotide exchange factor 26
  • Synonyms
    CSGEF, HMFN1864, SGEF
  • Links
    NCBI Gene ID: 26084
    neXtProt AC: NX_Q96DR7
    UniProt: Q96DR7

  • Chr Location
    3q25.2; chr3:154121003-154257827 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036885 Ensembl Gene Model | MGI Sequence Detail 123878 C57BL/6J ±  kb
transcript ENSMUST00000079300 Ensembl | MGI Sequence Detail 5638 Not Applicable  
polypeptide ENSMUSP00000078281 Ensembl | MGI Sequence Detail 869 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
less
MGI:1918810, MGI:2139660, MGI:2139988
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory