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Spag9 Gene Detail
Summary
  • Symbol
    Spag9
  • Name
    sperm associated antigen 9
  • Synonyms
    3110018C07Rik, 4733401I23Rik, 4831406C20Rik, JIP4, JLP, Mapk8ip4, syd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918084
    NCBI Gene: 70834
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:93886917-94016911 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2767 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918084
 protein coding gene Chr11:93886794-94016919 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018949
 protein coding gene Chr11:96036460-96179823 (+)
A/J MGP_AJ_G0018917
 protein coding gene Chr11:92224992-92351279 (+)
AKR/J MGP_AKRJ_G0018887
 protein coding gene Chr11:95097417-95229143 (+)
BALB/cJ MGP_BALBcJ_G0018890
 protein coding gene Chr11:92655379-92786508 (+)
C3H/HeJ MGP_C3HHeJ_G0018704
 protein coding gene Chr11:95170039-95301136 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019342
 protein coding gene Chr11:99026861-99169954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016973
 protein coding gene Chr11:89718926-89848002 (+)
CAST/EiJ MGP_CASTEiJ_G0018259
 protein coding gene Chr11:95867654-96004037 (+)
CBA/J MGP_CBAJ_G0018675
 protein coding gene Chr11:103133592-103281235 (+)
DBA/2J MGP_DBA2J_G0018783
 protein coding gene Chr11:91795177-91926353 (+)
FVB/NJ MGP_FVBNJ_G0018772
 protein coding gene Chr11:91208353-91336550 (+)
LP/J MGP_LPJ_G0018853
 protein coding gene Chr11:96596340-96727849 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018799
 protein coding gene Chr11:103192879-103340648 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019382
 protein coding gene Chr11:95290711-95429717 (+)
PWK/PhJ MGP_PWKPhJ_G0018029
 protein coding gene Chr11:92710855-92851254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017819
 protein coding gene Chr11:94975533-95104085 (+)
WSB/EiJ MGP_WSBEiJ_G0018308
 protein coding gene Chr11:95171563-95312001 (+)



Homology
more
  • Human Ortholog
    SPAG9, sperm associated antigen 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG9, sperm associated antigen 9
  • Synonyms
    CT89, HLC4, HLC-6, HLC6, JIP-4, JIP4, JLP, PHET, PIG6
  • Links
    NCBI Gene ID: 9043
    neXtProt AC: NX_O60271
    UniProt: O60271

  • Chr Location
    17q21.33; chr17:50962174-51120868 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SPAG9 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    40
  • cDNA Data
    27
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020859 Ensembl Gene Model | MGI Sequence Detail 129995 C57BL/6J ±  kb
    transcript ENSMUST00000041956 Ensembl | MGI Sequence Detail 7340 Not Applicable  
    polypeptide ENSMUSP00000042271 Ensembl | MGI Sequence Detail 1307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920413, MGI:1924388, MGI:2144568
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:354054 Tian M, et al., JLP/Foxk1/N-cadherin axis fosters a partial epithelial-mesenchymal transition state in epithelial tubular cells. iScience. 2023 Apr 21;26(4):106396
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory