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Agbl4 Gene Detail
Summary
  • Symbol
    Agbl4
  • Name
    ATP/GTP binding protein-like 4
  • Synonyms
    4930578N11Rik, 4931433A01Rik, Ccp6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918244
    NCBI Gene: 78933
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:110254858-111521521 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.43 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27907 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918244
 protein coding gene Chr4:110254823-111521521 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028577
 protein coding gene Chr4:111195394-112519871 (+)
A/J MGP_AJ_G0028540
 protein coding gene Chr4:107197461-108435013 (+)
AKR/J MGP_AKRJ_G0028487
 protein coding gene Chr4:109884546-111137014 (+)
BALB/cJ MGP_BALBcJ_G0028559
 protein coding gene Chr4:107403428-108660945 (+)
C3H/HeJ MGP_C3HHeJ_G0028273
 protein coding gene Chr4:110622149-111869875 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028999
 protein coding gene Chr4:115204913-116572567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026290
 protein coding gene Chr4:102475419-103607893 (+)
CAST/EiJ MGP_CASTEiJ_G0027709
 protein coding gene Chr4:108487340-109736674 (+)
CBA/J MGP_CBAJ_G0028242
 protein coding gene Chr4:118974666-120358593 (+)
DBA/2J MGP_DBA2J_G0028390
 protein coding gene Chr4:106824989-108095501 (+)
FVB/NJ MGP_FVBNJ_G0028358
 protein coding gene Chr4:105679047-106917965 (+)
LP/J MGP_LPJ_G0028491
 protein coding gene Chr4:111477876-112793811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028384
 protein coding gene Chr4:124212573-125748764 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029035
 protein coding gene Chr4:110114997-111385261 (+)
PWK/PhJ MGP_PWKPhJ_G0027435
 protein coding gene Chr4:105110524-106339699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027259
 protein coding gene Chr4:107522630-108742388 (+)
WSB/EiJ MGP_WSBEiJ_G0027790
 protein coding gene Chr4:110299131-111612844 (+)



Homology
more
  • Human Ortholog
    AGBL4, AGBL carboxypeptidase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGBL4, AGBL carboxypeptidase 4
  • Synonyms
    CCP6
  • Links
    NCBI Gene ID: 84871
    neXtProt AC: NX_Q5VU57
    UniProt: Q5VU57

  • Chr Location
    1p33; chr1:48522511-50023954 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal platelet morphology and physiology, impaired megakaryopoiesis, increased spleen weight and increased susceptibility to HSV or VACV infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    11
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061298 Ensembl Gene Model | MGI Sequence Detail 1266664 C57BL/6J ±  kb
    transcript ENSMUST00000097920 Ensembl | MGI Sequence Detail 1798 Not Applicable  
    polypeptide ENSMUSP00000095533 Ensembl | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1926183
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory