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Chd6 Gene Detail
Summary
  • Symbol
    Chd6
  • Name
    chromodomain helicase DNA binding protein 6
  • Synonyms
    5430439G14Rik, 6330406J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918639
    NCBI Gene: 71389
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:160788898-160950995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 80.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3485 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918639
 protein coding gene Chr2:160788898-160951006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026810
 protein coding gene Chr2:166153501-166321828 (-)
A/J MGP_AJ_G0026776
 protein coding gene Chr2:159474439-159640795 (-)
AKR/J MGP_AKRJ_G0026747
 protein coding gene Chr2:164193627-164364819 (-)
BALB/cJ MGP_BALBcJ_G0026785
 protein coding gene Chr2:159788288-159954760 (-)
C3H/HeJ MGP_C3HHeJ_G0026527
 protein coding gene Chr2:164525090-164691016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027234
 protein coding gene Chr2:171063023-171233811 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024604
 protein coding gene Chr2:152848165-153006883 (-)
CAST/EiJ MGP_CASTEiJ_G0025989
 protein coding gene Chr2:164907385-165078417 (-)
CBA/J MGP_CBAJ_G0026504
 protein coding gene Chr2:177227038-177402800 (-)
DBA/2J MGP_DBA2J_G0026642
 protein coding gene Chr2:158649485-158820667 (-)
FVB/NJ MGP_FVBNJ_G0026609
 protein coding gene Chr2:157055763-157216462 (-)
LP/J MGP_LPJ_G0026745
 protein coding gene Chr2:166256315-166431426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026630
 protein coding gene Chr2:180926282-181115174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027290
 protein coding gene Chr2:164030391-164198718 (-)
PWK/PhJ MGP_PWKPhJ_G0025723
 protein coding gene Chr2:158200773-158367643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025526
 protein coding gene Chr2:162909091-163072292 (-)
WSB/EiJ MGP_WSBEiJ_G0026059
 protein coding gene Chr2:164920196-165088439 (-)



Homology
more
  • Human Ortholog
    CHD6, chromodomain helicase DNA binding protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHD6, chromodomain helicase DNA binding protein 6
  • Synonyms
    CHD5, CHD-6, RIGB
  • Links
    NCBI Gene ID: 84181
    neXtProt AC: NX_Q8TD26
    UniProt: Q8TD26

  • Chr Location
    20q12; chr20:41402083-41618384 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    118
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057133 Ensembl Gene Model | MGI Sequence Detail 162098 C57BL/6J ±  kb
transcript ENSMUST00000039782 Ensembl | MGI Sequence Detail 10515 Not Applicable  
polypeptide ENSMUSP00000042291 Ensembl | MGI Sequence Detail 2711 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 118

    Microarray probesets 3
Other
Accession IDs
less
MGI:1921259
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory