Fmnl2 MGI Mouse Gene Detail - MGI:1918659 - formin-like 2

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Fmnl2 Gene Detail

Symbol

Fmnl2
Name

formin-like 2
Synonyms

5430425K04Rik, man

Feature Type

protein coding gene
IDs

MGI:1918659
NCBI Gene: 71409
Alliance

gene page
Transcription Start Sites

25 TSS

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Sequence Map

Chr2:52747872-53023816 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 30.69 cM
Mapping Data

1 experiment

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SNPs within 2kb

7633 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1918659	protein coding gene	Chr2:52747743-53023816 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025737	protein coding gene	Chr2:52227979-52522841 (+)
A/J	MGP_AJ_G0025713	protein coding gene	Chr2:50201723-50480872 (+)
AKR/J	MGP_AKRJ_G0025683	protein coding gene	Chr2:51633469-51925855 (+)
BALB/cJ	MGP_BALBcJ_G0025708	protein coding gene	Chr2:50305761-50585731 (+)
C3H/HeJ	MGP_C3HHeJ_G0025469	protein coding gene	Chr2:51655422-51950258 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026154	protein coding gene	Chr2:53754447-54047557 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023560	protein coding gene	Chr2:48170956-48450802 (+)
CAST/EiJ	MGP_CASTEiJ_G0024934	protein coding gene	Chr2:51760325-52068315 (+)
CBA/J	MGP_CBAJ_G0025449	protein coding gene	Chr2:55801482-56104771 (+)
DBA/2J	MGP_DBA2J_G0025580	protein coding gene	Chr2:49845619-50127161 (+)
FVB/NJ	MGP_FVBNJ_G0025542	protein coding gene	Chr2:49534216-49813970 (+)
LP/J	MGP_LPJ_G0025668	protein coding gene	Chr2:52124679-52423111 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025573	protein coding gene	Chr2:56799335-57101751 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026212	protein coding gene	Chr2:51572693-51860372 (+)
PWK/PhJ	MGP_PWKPhJ_G0024675	protein coding gene	Chr2:49732694-50016239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024481	protein coding gene	Chr2:51773268-52089767 (+)
WSB/EiJ	MGP_WSBEiJ_G0025001	protein coding gene	Chr2:51850535-52149801 (+)

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Human Ortholog

FMNL2, formin like 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FMNL2, formin like 2
Synonyms

FHOD2
Links

HGNC:18267

NCBI Gene ID: 114793

neXtProt AC: NX_Q96PY5

UniProt: Q96PY5
Chr Location

2q23.3; chr2:152335174-152649826 (+) GRCh38

MGI Vertebrate Homology

Fmnl2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FMNL2
Gene Tree

Fmnl2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

157
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

152
Targeted

1
Genomic Mutations

1 involving Fmnl2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

262 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

3
cDNA Data

67
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FMNL2

Xenbase fmnl2

ZFIN fmnl2a, fmnl2b

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All Sequences

71
RefSeq

24
UniProt

5
CCDS

CCDS38124.1

Ensembl

ENSMUSG00000036053 (Evidence)
NCBI Gene

71409

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000036053	Ensembl Gene Model \| MGI Sequence Detail	275945	C57BL/6J	± kb
	transcript	ENSMUST00000090952	Ensembl \| MGI Sequence Detail	5414	Not Applicable
	polypeptide	ENSMUSP00000088472	Ensembl \| MGI Sequence Detail	1091	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007572 formin-like protein 2

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR014767 Diaphanous autoregulatory (DAD) domain

IPR015425 Formin, FH2 domain

IPR042201 Formin, FH2 domain superfamily

IPR010472 Formin, FH3 domain

IPR010473 Formin, GTPase-binding domain

IPR043592 Formin-like protein, animal

IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
GlyGen

A2APV2 1 site, 1 N-linked glycan (1 site)

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All nucleic 69

cDNA 67

Primer pair 2

Microarray probesets 4

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Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fmnl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17730	Chr2:52747756-52747810 (+)	-89 bp
Tssr17731	Chr2:52747813-52747838 (+)	-46 bp
Tssr17732	Chr2:52747840-52747849 (+)	-27 bp
Tssr17733	Chr2:52747856-52747863 (+)	-12 bp
Tssr17736	Chr2:52762133-52762145 (+)	14,267 bp
Tssr17737	Chr2:52762183-52762208 (+)	14,324 bp
Tssr17738	Chr2:52772017-52772021 (+)	24,147 bp
Tssr17739	Chr2:52782130-52782135 (+)	34,261 bp
Tssr17740	Chr2:52789398-52789401 (+)	41,528 bp
Tssr17741	Chr2:52817624-52817654 (+)	69,767 bp
Tssr17742	Chr2:52817655-52817667 (+)	69,789 bp
Tssr17743	Chr2:52828652-52828682 (+)	80,795 bp
Tssr17744	Chr2:52842681-52842716 (+)	94,827 bp
Tssr17745	Chr2:52857689-52857699 (+)	109,822 bp
Tssr17746	Chr2:52857700-52857711 (+)	109,834 bp
Tssr17747	Chr2:52857716-52857727 (+)	109,850 bp
Tssr17748	Chr2:52866952-52866960 (+)	119,084 bp
Tssr17749	Chr2:52872760-52872761 (+)	124,889 bp
Tssr17750	Chr2:52905508-52905512 (+)	157,638 bp
Tssr17751	Chr2:52944554-52944581 (+)	196,696 bp
Tssr17752	Chr2:52993737-52993750 (+)	245,872 bp
Tssr17753	Chr2:52997602-52997641 (+)	249,750 bp
Tssr17754	Chr2:53013884-53013898 (+)	266,019 bp
Tssr17755	Chr2:53018877-53018882 (+)	271,008 bp
Tssr17756	Chr2:53022823-53022837 (+)	274,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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