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Piezo2 Gene Detail
Summary
  • Symbol
    Piezo2
  • Name
    piezo-type mechanosensitive ion channel component 2
  • Synonyms
    9030411M15Rik, 9430028L06Rik, Fam38b, Fam38b2, Piezo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918781
    NCBI Gene: 667742
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:63143284-63520254 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 35.95 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11960 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918781
 protein coding gene Chr18:63143284-63520787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024498
 protein coding gene Chr18:62970776-63394565 (-)
A/J MGP_AJ_G0024465
 protein coding gene Chr18:60288425-60674151 (-)
AKR/J MGP_AKRJ_G0024435
 protein coding gene Chr18:61947193-62374447 (-)
BALB/cJ MGP_BALBcJ_G0024464
 protein coding gene Chr18:60430329-60812128 (-)
C3H/HeJ MGP_C3HHeJ_G0024232
 protein coding gene Chr18:62192935-62591662 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024911
 protein coding gene Chr18:64683701-65110149 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022342
 protein coding gene Chr18:59792319-60149511 (-)
CAST/EiJ MGP_CASTEiJ_G0023705
 protein coding gene Chr18:62065255-62458505 (-)
CBA/J MGP_CBAJ_G0024202
 protein coding gene Chr18:66788488-67214756 (-)
DBA/2J MGP_DBA2J_G0024332
 protein coding gene Chr18:59941625-60330764 (-)
FVB/NJ MGP_FVBNJ_G0024298
 protein coding gene Chr18:59341075-59721347 (-)
LP/J MGP_LPJ_G0024416
 protein coding gene Chr18:62859173-63266928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024327
 protein coding gene Chr18:68309897-68732910 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024958
 protein coding gene Chr18:62161238-62576183 (-)
PWK/PhJ MGP_PWKPhJ_G0023448
 protein coding gene Chr18:60181346-60561854 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023253
 protein coding gene Chr18:62362504-62753380 (-)
WSB/EiJ MGP_WSBEiJ_G0023769
 protein coding gene Chr18:62014081-62419068 (-)



Homology
more
  • Human Ortholog
    PIEZO2, piezo type mechanosensitive ion channel component 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIEZO2, piezo type mechanosensitive ion channel component 2
  • Synonyms
    C18orf30, C18orf58, DA3, DA5, DAIPT, FAM38B, FAM38B2, HsT748, HsT771, MWKS
  • Links
    NCBI Gene ID: 63895
    neXtProt AC: NX_Q9H5I5
    UniProt: Q9H5I5

  • Chr Location
    18p11.22-p11.21; chr18:10666483-11149569 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PIEZO2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired injury-induced tactile pain detection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    7
  • cDNA Data
    28
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041482 Ensembl Gene Model | MGI Sequence Detail 376971 C57BL/6J ±  kb
    transcript ENSMUST00000047480 Ensembl | MGI Sequence Detail 10724 Not Applicable  
    polypeptide ENSMUSP00000040019 Ensembl | MGI Sequence Detail 2824 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442541
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 67
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358157 N'Guetta PY, et al., Comprehensive mapping of sensory and sympathetic innervation of the developing kidney. Cell Rep. 2024 Oct 22;43(10):114860
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory