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Shtn1 Gene Detail
Summary
  • Symbol
    Shtn1
  • Name
    shootin 1
  • Synonyms
    4930506M07Rik, shootin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918903
    NCBI Gene: 71653
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:58961788-59064532 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 54.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2511 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918903
 protein coding gene Chr19:58961788-59064536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025284
 protein coding gene Chr19:59471624-59579615 (-)
A/J MGP_AJ_G0025260
 protein coding gene Chr19:56562882-56665067 (-)
AKR/J MGP_AKRJ_G0025229
 protein coding gene Chr19:58327000-58432086 (-)
BALB/cJ MGP_BALBcJ_G0025255
 protein coding gene Chr19:56634331-56735427 (-)
C3H/HeJ MGP_C3HHeJ_G0025015
 protein coding gene Chr19:58584895-58686548 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025698
 protein coding gene Chr19:60912822-61015045 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023110
 protein coding gene Chr19:55444426-55546577 (-)
CAST/EiJ MGP_CASTEiJ_G0024480
 protein coding gene Chr19:58664944-58768064 (-)
CBA/J MGP_CBAJ_G0024995
 protein coding gene Chr19:63886611-63990642 (-)
DBA/2J MGP_DBA2J_G0025127
 protein coding gene Chr19:56310965-56411734 (-)
FVB/NJ MGP_FVBNJ_G0025088
 protein coding gene Chr19:56050879-56151670 (-)
LP/J MGP_LPJ_G0025213
 protein coding gene Chr19:59353497-59457836 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025121
 protein coding gene Chr19:63118146-63220761 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025756
 protein coding gene Chr19:58562375-58665139 (-)
PWK/PhJ MGP_PWKPhJ_G0024228
 protein coding gene Chr19:56314697-56416337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024031
 protein coding gene Chr19:57228278-57332260 (-)
WSB/EiJ MGP_WSBEiJ_G0024550
 protein coding gene Chr19:58679960-58782144 (-)



Homology
more
  • Human Ortholog
    SHTN1, shootin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHTN1, shootin 1
  • Synonyms
    KIAA1598, shootin-1
  • Links
    NCBI Gene ID: 57698
    neXtProt AC: NX_A0MZ66
    UniProt: A0MZ66

  • Chr Location
    10q25.3; chr10:116881477-117126586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal projection of the forebrain commissural axons and partial postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    39
  • cDNA Data
    7
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041362 Ensembl Gene Model | MGI Sequence Detail 102745 C57BL/6J ±  kb
    transcript ENSMUST00000047511 Ensembl | MGI Sequence Detail 3974 Not Applicable  
    polypeptide ENSMUSP00000041378 Ensembl | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350578 Zhang K, et al., Shootin1 Regulates Retinal Ganglion Cell Neurite Development: Insights From an RGC Direct Somatic Cell Reprogramming Model. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):41
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory