Tube1 MGI Mouse Gene Detail - MGI:1919174

Symbol

Tube1
Name

tubulin, epsilon 1
Synonyms

2310061K05Rik

Feature Type

protein coding gene
IDs

MGI:1919174
NCBI Gene: 71924
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:39009972-39028538 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 20.16 cM, cytoband B1
Mapping Data

4 experiments

SNPs within 2kb

671 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919174	protein coding gene	Chr10:39009946-39035863 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017149	protein coding gene	Chr10:37623652-37641862 (+)
A/J	MGP_AJ_G0017126	protein coding gene	Chr10:36631061-36648116 (+)
AKR/J	MGP_AKRJ_G0017086	protein coding gene	Chr10:37132661-37150435 (+)
BALB/cJ	MGP_BALBcJ_G0017089	protein coding gene	Chr10:36657325-36674693 (+)
C3H/HeJ	MGP_C3HHeJ_G0016909	protein coding gene	Chr10:37453661-37471574 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017547	protein coding gene	Chr10:38788110-38806685 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015244	protein coding gene	Chr10:34621403-34639039 (+)
CAST/EiJ	MGP_CASTEiJ_G0016488	protein coding gene	Chr10:37597636-37616487 (+)
CBA/J	MGP_CBAJ_G0016883	protein coding gene	Chr10:40583518-40604315 (+)
DBA/2J	MGP_DBA2J_G0016988	protein coding gene	Chr10:36152734-36169779 (+)
FVB/NJ	MGP_FVBNJ_G0016983	protein coding gene	Chr10:35654376-35671372 (+)
LP/J	MGP_LPJ_G0017065	protein coding gene	Chr10:37594817-37612759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017013	protein coding gene	Chr10:41465381-41483757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017583	protein coding gene	Chr10:37120578-37137841 (+)
PWK/PhJ	MGP_PWKPhJ_G0016269	protein coding gene	Chr10:35974761-35992051 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016053	protein coding gene	Chr10:36895455-36912654 (+)
WSB/EiJ	MGP_WSBEiJ_G0016551	protein coding gene	Chr10:37395185-37412181 (+)

Human Ortholog

TUBE1, tubulin epsilon 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUBE1, tubulin epsilon 1
Synonyms

dJ142L7.2, TUBE
Links

HGNC:20775

NCBI Gene ID: 51175

neXtProt AC: NX_Q9UJT0

UniProt: Q9UJT0
Chr Location

6q21; chr6:112070663-112087529 (-) GRCh38

MGI Vertebrate Homology

Tube1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TUBE1
Gene Tree

Tube1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tube1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

32
cDNA Data

33
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tube1

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All Sequences

53
RefSeq

12
UniProt

2
CCDS

CCDS23787.1

Ensembl

ENSMUSG00000019845 (Evidence)
NCBI Gene

71924

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019845	Ensembl Gene Model \| MGI Sequence Detail	18567	C57BL/6J	± kb
transcript	ENSMUST00000019991	Ensembl \| MGI Sequence Detail	2929	Not Applicable
polypeptide	ENSMUSP00000019991	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016824 tubulin epsilon chain

(term hierarchy)
InterPro Domains

IPR004057 Epsilon tubulin

IPR000217 Tubulin

IPR017975 Tubulin, conserved site

IPR023123 Tubulin, C-terminal

IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

IPR008280 Tubulin/FtsZ, C-terminal

IPR003008 Tubulin/FtsZ, GTPase domain

IPR036525 Tubulin/FtsZ, GTPase domain superfamily

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All nucleic 34

cDNA 33

Primer pair 1

Microarray probesets 4

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MGI:2143644

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:297664 Simonson L, et al., Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153

TSS for Tube1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92973	Chr10:39009954-39009976 (+)	-7 bp
Tssr92974	Chr10:39009977-39010027 (+)	30 bp
Tssr92975	Chr10:39010046-39010062 (+)	82 bp
Tssr92976	Chr10:39012933-39012959 (+)	2,974 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24