About   Help   FAQ
Nkiras2 Gene Detail
Summary
  • Symbol
    Nkiras2
  • Name
    NFKB inhibitor interacting Ras-like protein 2
  • Synonyms
    2410003M04Rik, 4930527H08Rik, KBRAS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919216
    NCBI Gene: 71966
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100510070-100518433 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919216
 protein coding gene Chr11:100510007-100518436 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019162
 protein coding gene Chr11:103385901-103394314 (+)
A/J MGP_AJ_G0019130
 protein coding gene Chr11:99070613-99078975 (+)
AKR/J MGP_AKRJ_G0019099
 protein coding gene Chr11:102135894-102144305 (+)
BALB/cJ MGP_BALBcJ_G0019104
 protein coding gene Chr11:99554955-99563315 (+)
C3H/HeJ MGP_C3HHeJ_G0018913
 protein coding gene Chr11:102318776-102327452 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019553
 protein coding gene Chr11:106599767-106608104 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017179
 protein coding gene Chr11:96491061-96499452 (+)
CAST/EiJ MGP_CASTEiJ_G0018467
 protein coding gene Chr11:103298015-103305826 (+)
CBA/J MGP_CBAJ_G0018882
 protein coding gene Chr11:111037604-111050339 (+)
DBA/2J MGP_DBA2J_G0018994
 protein coding gene Chr11:98607423-98616001 (+)
FVB/NJ MGP_FVBNJ_G0018984
 protein coding gene Chr11:98143572-98152894 (+)
LP/J MGP_LPJ_G0019063
 protein coding gene Chr11:103947545-103956701 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019015
 protein coding gene Chr11:110638304-110647540 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019591
 protein coding gene Chr11:102467172-102475536 (+)
PWK/PhJ MGP_PWKPhJ_G0018230
 protein coding gene Chr11:99648553-99656953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018022
 protein coding gene Chr11:102207105-102217396 (+)
WSB/EiJ MGP_WSBEiJ_G0018516
 protein coding gene Chr11:102450970-102459131 (+)



Homology
more
  • Human Ortholog
    NKIRAS2, NFKB inhibitor interacting Ras like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKIRAS2, NFKB inhibitor interacting Ras like 2
  • Synonyms
    kappaB-Ras2, KBRAS2
  • Links
    NCBI Gene ID: 28511
    neXtProt AC: NX_Q9NYR9
    UniProt: Q9NYR9

  • Chr Location
    17q21.2; chr17:42011382-42025644 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017837 Ensembl Gene Model | MGI Sequence Detail 8364 C57BL/6J ±  kb
transcript ENSMUST00000107376 Ensembl | MGI Sequence Detail 1727 Not Applicable  
polypeptide ENSMUSP00000102999 Ensembl | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011236 NF-kappa-B inhibitor-interacting Ras-like protein 2
    (term hierarchy)
  • InterPro Domains
    IPR042227 NF-kappa-B inhibitor-interacting Ras-like protein
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922407
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory