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Igsf5 Gene Detail
Summary
  • Symbol
    Igsf5
  • Name
    immunoglobulin superfamily, member 5
  • Synonyms
    2010003D20Rik, Igsf5, Jam4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919308
    NCBI Gene: 72058
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96162868-96223321 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.93 cM, cytoband C4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919308
 protein coding gene Chr16:96162676-96266772 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023085
 protein coding gene Chr16:97742917-97912406 (+)
A/J MGP_AJ_G0023053
 protein coding gene Chr16:93100290-93280129 (+)
AKR/J MGP_AKRJ_G0023023
 protein coding gene Chr16:95977817-96147724 (+)
BALB/cJ MGP_BALBcJ_G0023055
 protein coding gene Chr16:93666052-93831472 (+)
C3H/HeJ MGP_C3HHeJ_G0022816
 protein coding gene Chr16:96507230-96674019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023502
 protein coding gene Chr16:100844507-101010230 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021004
 protein coding gene Chr16:90963888-91121171 (+)
CAST/EiJ MGP_CASTEiJ_G0022336
 protein coding gene Chr16:97304496-97474161 (+)
CBA/J MGP_CBAJ_G0022785
 protein coding gene Chr16:105201208-105377221 (+)
DBA/2J MGP_DBA2J_G0022919
 protein coding gene Chr16:92992271-93154060 (+)
FVB/NJ MGP_FVBNJ_G0022893
 protein coding gene Chr16:92168026-92325520 (+)
LP/J MGP_LPJ_G0022989
 protein coding gene Chr16:97387890-97553238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022914
 protein coding gene Chr16:109414333-109586618 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023520
 protein coding gene Chr16:96518016-96681069 (+)
PWK/PhJ MGP_PWKPhJ_G0022080
 protein coding gene Chr16:93290042-93448487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021910
 protein coding gene Chr16:96055238-96224801 (+)
WSB/EiJ MGP_WSBEiJ_G0022386
 protein coding gene Chr16:96775364-96951784 (+)



Homology
more
  • Human Ortholog
    IGSF5, immunoglobulin superfamily member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGSF5, immunoglobulin superfamily member 5
  • Synonyms
    GSF5, JAM4
  • Links
    NCBI Gene ID: 150084
    neXtProt AC: NX_Q9NSI5
    UniProt: Q9NSI5

  • Chr Location
    21q22.2; chr21:39711771-39802081 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    91 phenotype references
Homozygous mutation of this gene results in no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1051
  • Tissues
    197
  • cDNA Data
    22
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000159 Ensembl Gene Model | MGI Sequence Detail 60454 C57BL/6J ±  kb
transcript ENSMUST00000113794 Ensembl | MGI Sequence Detail 1601 Not Applicable  
polypeptide ENSMUSP00000109425 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 22
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2652099
References
more
  • Summaries
    All 122
    Developmental Gene Expression 7
    Diseases 6
    Gene Ontology 3
    Phenotypes 91
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory