Cyp2c55 MGI Mouse Gene Detail - MGI:1919332 - cytochrome P450, family 2, subfamily c, polypeptide 55

Symbol

Cyp2c55
Name

cytochrome P450, family 2, subfamily c, polypeptide 55
Synonyms

2010318C06Rik

Feature Type

protein coding gene
IDs

MGI:1919332
NCBI Gene: 72082
Alliance

gene page
Transcription Start Sites

43 TSS

Sequence Map

Chr19:38995463-39031137 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 33.64 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

1239 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919332	protein coding gene	Chr19:38995384-39031137 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025097	protein coding gene	Chr19:38125266-38174113 (+)
A/J	MGP_AJ_G0025073	protein coding gene	Chr19:36268811-36311559 (+)
AKR/J	MGP_AKRJ_G0025041	protein coding gene	Chr19:37471978-37518381 (+)
BALB/cJ	MGP_BALBcJ_G0025071	protein coding gene	Chr19:36357929-36405541 (+)
C3H/HeJ	MGP_C3HHeJ_G0024830	protein coding gene	Chr19:37579327-37616228 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025512	protein coding gene	Chr19:39185946-39224129 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022931	protein coding gene	Chr19:35569149-35604766 (+)
CAST/EiJ	MGP_CASTEiJ_G0024297	protein coding gene	Chr19:37441755-37481356 (+)
CBA/J	MGP_CBAJ_G0024807	protein coding gene	Chr19:41062849-41121914 (+)
DBA/2J	MGP_DBA2J_G0024939	protein coding gene	Chr19:36099784-36136109 (+)
FVB/NJ	MGP_FVBNJ_G0024900	protein coding gene	Chr19:35923908-35961895 (+)
LP/J	MGP_LPJ_G0025025	protein coding gene	Chr19:38188451-38230141 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024931	protein coding gene	Chr19:40771560-40807536 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025570	protein coding gene	Chr19:37593934-37633493 (+)
PWK/PhJ	MGP_PWKPhJ_G0024049	protein coding gene	Chr19:35974863-36011784 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023849	protein coding gene	Chr19:36419555-36454665 (+)
WSB/EiJ	MGP_WSBEiJ_G0024364	protein coding gene	Chr19:37684633-37723250 (+)

Human Ortholog

CYP2C18, cytochrome P450 family 2 subfamily C member 18

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2C18, cytochrome P450 family 2 subfamily C member 18
Synonyms

CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
Links

HGNC:2620

NCBI Gene ID: 1562

neXtProt AC: NX_P33260

UniProt: P33260
Chr Location

10q23.33; chr10:94683729-94736190 (+) GRCh38

MGI Vertebrate Homology

Cyp2c55 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP2C18
Gene Tree

Cyp2c55

Diseases

21 with human CYP2C19,CYP2C8,CYP2C9 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				end stage renal disease IDs end stage renal disease DOID:783
				eosinophilic esophagitis IDs eosinophilic esophagitis DOID:13922 EFO:0004232 ICD10CM:K20.0 ICD9CM:530.13 MESH:D057765 NCI:C27105 OMIM:610247 OMIM:613412 ORDO:73247 UMLS_CUI:C0341106
				head and neck squamous cell carcinoma IDs head and neck squamous cell carcinoma DOID:5520 MESH:D000077195 NCI:C34447 OMIM:275355 UMLS_CUI:C1168401
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				heroin dependence IDs heroin dependence DOID:9976 MESH:D006556 NCI:C34694 UMLS_CUI:C0019337
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				hypoglycemia IDs hypoglycemia DOID:9993 ICD10CM:E16.2 ICD9CM:251.2 MESH:D007003 NCI:C3126 UMLS_CUI:C0020615
				invasive aspergillosis IDs invasive aspergillosis DOID:0050073
				multiple chemical sensitivity IDs multiple chemical sensitivity DOID:4661 MESH:D018777 UMLS_CUI:C0242992
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				peptic ulcer disease IDs peptic ulcer disease DOID:750 DOID:11466 DOID:12635 DOID:13115 ICD10CM:K27 ICD9CM:533 MESH:D010437 NCI:C3318 UMLS_CUI:C0030920
				Plasmodium falciparum malaria IDs Plasmodium falciparum malaria DOID:14067 ICD10CM:B50 ICD9CM:084.0 ICD9CM_2006:084.0 MESH:D016778 NCI:C34798 UMLS_CUI:C0024535
				renal hypertension IDs renal hypertension DOID:1073 MESH:D006977 NCI:C3121 UMLS_CUI:C0020544
				sickle cell anemia IDs sickle cell anemia DOID:10923 DOID:12924 DOID:13024 ICD10CM:D57.1 ICD10CM:D57.2 ICD9CM_2006:282.63 ICD9CM:282.6 ICD9CM:282.60 ICD9CM:282.63 MESH:D000755 MESH:D006450 NCI:C34383 NCI:C34676 ORDO:232 UMLS_CUI:C0002895 UMLS_CUI:C0019034
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				warfarin resistance IDs warfarin resistance DOID:0080665 OMIM:122700

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Cyp2c55
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

30
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

4
UniProt

1
CCDS

CCDS29790.1

Ensembl

ENSMUSG00000025002 (Evidence)
NCBI Gene

72082

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025002	Ensembl Gene Model \| MGI Sequence Detail	35675	C57BL/6J	± kb
transcript	ENSMUST00000025966	Ensembl \| MGI Sequence Detail	1995	Not Applicable
polypeptide	ENSMUSP00000025966	Ensembl \| MGI Sequence Detail	490	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006232 cytochrome P450 2C55

(term hierarchy)
EC

1.14.14.1
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR050182 Cytochrome P450 family 2

IPR036396 Cytochrome P450 superfamily

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All nucleic 32

cDNA 30

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341617 Zhang J, et al., CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J. 2023 Jul;37(7):e23009

TSS for Cyp2c55:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156280	Chr19:38995358-38995367 (+)	-100 bp
Tssr156281	Chr19:38995392-38995416 (+)	-59 bp
Tssr156282	Chr19:38995495-38995537 (+)	53 bp
Tssr156283	Chr19:38995581-38995592 (+)	124 bp
Tssr156284	Chr19:38995606-38995609 (+)	145 bp
Tssr156285	Chr19:38999582-38999588 (+)	4,122 bp
Tssr156286	Chr19:39000133-39000138 (+)	4,673 bp
Tssr156287	Chr19:39000166-39000171 (+)	4,706 bp
Tssr156288	Chr19:39000205-39000248 (+)	4,764 bp
Tssr156289	Chr19:39005194-39005205 (+)	9,737 bp
Tssr156290	Chr19:39005357-39005374 (+)	9,903 bp
Tssr156291	Chr19:39006913-39006942 (+)	11,465 bp
Tssr156292	Chr19:39007178-39007186 (+)	11,719 bp
Tssr156293	Chr19:39007247-39007254 (+)	11,788 bp
Tssr156294	Chr19:39007872-39007910 (+)	12,428 bp
Tssr156295	Chr19:39010492-39010501 (+)	15,034 bp
Tssr156296	Chr19:39010548-39010568 (+)	15,095 bp
Tssr156297	Chr19:39011178-39011186 (+)	15,719 bp
Tssr156298	Chr19:39011210-39011217 (+)	15,751 bp
Tssr156299	Chr19:39011822-39011832 (+)	16,364 bp
Tssr5498	Chr19:39011907-39011908 (+)	16,445 bp
Tssr156300	Chr19:39011994-39012005 (+)	16,537 bp
Tssr156301	Chr19:39012357-39012371 (+)	16,901 bp
Tssr156302	Chr19:39012389-39012396 (+)	16,930 bp
Tssr156303	Chr19:39012401-39012413 (+)	16,944 bp
Tssr156304	Chr19:39012507-39012515 (+)	17,048 bp
Tssr5499	Chr19:39014286-39014293 (+)	18,827 bp
Tssr156305	Chr19:39014432-39014441 (+)	18,974 bp
Tssr156306	Chr19:39018676-39018691 (+)	23,221 bp
Tssr156307	Chr19:39018761-39018763 (+)	23,299 bp
Tssr156308	Chr19:39019703-39019714 (+)	24,246 bp
Tssr156309	Chr19:39019745-39019750 (+)	24,285 bp
Tssr156310	Chr19:39019798-39019805 (+)	24,339 bp
Tssr5500	Chr19:39019847-39019849 (+)	24,385 bp
Tssr156311	Chr19:39023759-39023768 (+)	28,301 bp
Tssr156312	Chr19:39024076-39024088 (+)	28,619 bp
Tssr156313	Chr19:39024391-39024395 (+)	28,930 bp
Tssr156314	Chr19:39024924-39024935 (+)	29,467 bp
Tssr156315	Chr19:39024982-39024987 (+)	29,522 bp
Tssr156316	Chr19:39025481-39025482 (+)	30,019 bp
Tssr5501	Chr19:39026540-39026556 (+)	31,085 bp
Tssr156317	Chr19:39030473-39030511 (+)	35,029 bp
Tssr156318	Chr19:39030718-39030730 (+)	35,261 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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