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Bag6 Gene Detail
Summary
  • Symbol
    Bag6
  • Name
    BCL2-associated athanogene 6
  • Synonyms
    2410045D21Rik, Bat3, D17H6S52E, G3, Scythe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919439
    NCBI Gene: 224727
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35354154-35366298 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919439
 protein coding gene Chr17:35354132-35366298 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023623
 protein coding gene Chr17:35278110-35290254 (+)
A/J MGP_AJ_G0023583
 protein coding gene Chr17:34107857-34119988 (+)
AKR/J MGP_AKRJ_G0023551
 protein coding gene Chr17:34584975-34597125 (+)
BALB/cJ MGP_BALBcJ_G0023589
 protein coding gene Chr17:34247572-34259703 (+)
C3H/HeJ MGP_C3HHeJ_G0023350
 protein coding gene Chr17:34986146-34998302 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024028
 protein coding gene Chr17:36621714-36633858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021509
 protein coding gene Chr17:31877685-31890250 (+)
CAST/EiJ MGP_CASTEiJ_G0022846
 protein coding gene Chr17:34981486-34993637 (+)
CBA/J MGP_CBAJ_G0023328
 protein coding gene Chr17:38129563-38141719 (+)
DBA/2J MGP_DBA2J_G0023456
 protein coding gene Chr17:33432177-33444308 (+)
FVB/NJ MGP_FVBNJ_G0023423
 protein coding gene Chr17:33271436-33285578 (+)
LP/J MGP_LPJ_G0023533
 protein coding gene Chr17:35606961-35619105 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023445
 protein coding gene Chr17:37058699-37070843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024073
 protein coding gene Chr17:34809370-34821516 (+)
PWK/PhJ MGP_PWKPhJ_G0022594
 protein coding gene Chr17:32266348-32278533 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022414
 protein coding gene Chr17:32818433-32830703 (+)
WSB/EiJ MGP_WSBEiJ_G0022910
 protein coding gene Chr17:34931400-34943556 (+)



Homology
more
  • Human Ortholog
    BAG6, BAG cochaperone 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAG6, BAG cochaperone 6
  • Synonyms
    BAG-6, BAT3, D6S52E, G3
  • Links
    NCBI Gene ID: 7917
    neXtProt AC: NX_P46379
    UniProt: P46379

  • Chr Location
    6p21.33; chr6:31639028-31652705 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BAG6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in either embryonic lethality following abnormal brain development or neonatal death associated with severe developmental defects in the lung and kidney. These developmental defects are associated with widespread aberrant apoptosis and proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    90
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    3
  • cDNA Data
    261
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024392 Ensembl Gene Model | MGI Sequence Detail 12145 C57BL/6J ±  kb
    transcript ENSMUST00000025250 Ensembl | MGI Sequence Detail 3858 Not Applicable  
    polypeptide ENSMUSP00000025250 Ensembl | MGI Sequence Detail 1154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 282
      Genomic 17
      cDNA 263
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1508, MGD-MRK-16249, MGI:2146754, MGI:99475
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 9
    • Earliest
      J:1314 Lafuse WP, et al., PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex. Immunogenetics. 1992;36(2):110-6
    • Latest
      J:301217 Xu J, et al., The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion. Exp Cell Res. 2020 Nov 15;396(2):112310
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory