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Uaca Gene Detail
Summary
  • Symbol
    Uaca
  • Name
    uveal autoantigen with coiled-coil domains and ankyrin repeats
  • Synonyms
    2700059D02Rik, nucling
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919815
    NCBI Gene: 72565
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:60701824-60787652 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 32.93 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2486 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919815
 protein coding gene Chr9:60700488-60787713 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034912
 protein coding gene Chr9:60215113-60310928 (+)
A/J MGP_AJ_G0034892
 protein coding gene Chr9:58277707-58365567 (+)
AKR/J MGP_AKRJ_G0034822
 protein coding gene Chr9:59627671-59712662 (+)
BALB/cJ MGP_BALBcJ_G0034885
 protein coding gene Chr9:57992352-58079468 (+)
C3H/HeJ MGP_C3HHeJ_G0034595
 protein coding gene Chr9:60108820-60202459 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035404
 protein coding gene Chr9:61869493-61957381 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032315
 protein coding gene Chr9:57974494-58058782 (+)
CAST/EiJ MGP_CASTEiJ_G0033916
 protein coding gene Chr9:60214581-60300644 (+)
CBA/J MGP_CBAJ_G0034566
 protein coding gene Chr9:64016975-64106883 (+)
DBA/2J MGP_DBA2J_G0034725
 protein coding gene Chr9:58078459-58166017 (+)
FVB/NJ MGP_FVBNJ_G0034667
 protein coding gene Chr9:57357320-57443309 (+)
LP/J MGP_LPJ_G0034808
 protein coding gene Chr9:60521042-60611111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034710
 protein coding gene Chr9:65491218-65582651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035426
 protein coding gene Chr9:59648989-59740381 (+)
PWK/PhJ MGP_PWKPhJ_G0033620
 protein coding gene Chr9:58169483-58256194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033453
 protein coding gene Chr9:59928237-60016788 (+)
WSB/EiJ MGP_WSBEiJ_G0034029
 protein coding gene Chr9:59580819-59673151 (+)



Homology
more
  • Human Ortholog
    UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UACA, uveal autoantigen with coiled-coil domains and ankyrin repeats
  • Synonyms
    NUCLING
  • Links
    NCBI Gene ID: 55075
    neXtProt AC: NX_Q9BZF9
    UniProt: Q9BZF9

  • Chr Location
    15q23; chr15:70654554-70778903 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Uaca mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display swelling of and inflammatory lesions in the preputial gland.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    15
  • cDNA Data
    88
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034485 Ensembl Gene Model | MGI Sequence Detail 85829 C57BL/6J ±  kb
    transcript ENSMUST00000050183 Ensembl | MGI Sequence Detail 4428 Not Applicable  
    polypeptide ENSMUSP00000062047 Ensembl | MGI Sequence Detail 1413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016947 uveal autoantigen with coiled-coil domains and ankyrin repeats
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR000727 Target SNARE coiled-coil homology domain
    • GlyGen
      Q8CGB3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 5
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:244571 Kim SM, et al., Nucling, a novel protein associated with NF-kappaB, regulates endotoxin-induced apoptosis in vivo. J Biochem. 2013 Jan;153(1):93-101
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory