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Vps50 Gene Detail
Summary
  • Symbol
    Vps50
  • Name
    VPS50 EARP/GARPII complex subunit
  • Synonyms
    1700034M03Rik, 8430415E05Rik, Ccdc132, mKIAA1861
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920538
    NCBI Gene: 73288
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:3498393-3603531 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.81 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920538
 protein coding gene Chr6:3498382-3603531 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030421
 protein coding gene Chr6:225029-350456 (+)
A/J MGP_AJ_G0030394
 protein coding gene Chr6:224128-324110 (+)
AKR/J MGP_AKRJ_G0030321
 protein coding gene Chr6:255040-360647 (+)
BALB/cJ MGP_BALBcJ_G0030403
 protein coding gene Chr6:208183-309127 (+)
C3H/HeJ MGP_C3HHeJ_G0030117
 protein coding gene Chr6:217876-321110 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030858
 protein coding gene Chr6:211897-319707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028069
 protein coding gene Chr6:62207-163263 (+)
CAST/EiJ MGP_CASTEiJ_G0029518
 protein coding gene Chr6:220283-333667 (+)
CBA/J MGP_CBAJ_G0030095
 protein coding gene Chr6:247991-362556 (+)
DBA/2J MGP_DBA2J_G0030239
 protein coding gene Chr6:206219-307261 (+)
FVB/NJ MGP_FVBNJ_G0030193
 protein coding gene Chr6:221074-324468 (+)
LP/J MGP_LPJ_G0030326
 protein coding gene Chr6:228023-332321 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030229
 protein coding gene Chr6:262563-373063 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030888
 protein coding gene Chr6:211051-310814 (+)
PWK/PhJ MGP_PWKPhJ_G0029233
 protein coding gene Chr6:166460-269858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029069
 protein coding gene Chr6:228781-332362 (+)
WSB/EiJ MGP_WSBEiJ_G0029595
 protein coding gene Chr6:208130-313901 (+)



Homology
more
  • Human Ortholog
    VPS50, VPS50 subunit of EARP/GARPII complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS50, VPS50 subunit of EARP/GARPII complex
  • Synonyms
    CCDC132, NEDMSC, VPS54L
  • Links
    NCBI Gene ID: 55610
    neXtProt AC: NX_Q96JG6
    UniProt: Q96JG6

  • Chr Location
    7q21.2-q21.3; chr7:93232340-93361123 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    94
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 73288 NCBI Gene Model | MGI Sequence Detail 105139 C57BL/6J ±  kb
transcript NM_001167750 RefSeq | MGI Sequence Detail 5072 C57BL/6  
polypeptide Q8CI71 UniProt | EBI | MGI Sequence Detail 964 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    cDNA 94

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918738, MGI:2141784
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:350299 Ahumada-Marchant C, et al., Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior. BMC Biol. 2024 Jun 26;22(1):142
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory