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Vsir Gene Detail
Summary
  • Symbol
    Vsir
  • Name
    V-set immunoregulatory receptor
  • Synonyms
    4632428N05Rik, Dies1, PD-1H, VISTA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921298
    NCBI Gene: 74048
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:60182630-60208463 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 30.26 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    773 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921298
 protein coding gene Chr10:60182630-60266073 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017269
 protein coding gene Chr10:59573286-59598994 (+)
A/J MGP_AJ_G0017247
 protein coding gene Chr10:57830205-57857289 (+)
AKR/J MGP_AKRJ_G0017207
 protein coding gene Chr10:59333652-59359832 (+)
BALB/cJ MGP_BALBcJ_G0017207
 protein coding gene Chr10:57911499-57937588 (+)
C3H/HeJ MGP_C3HHeJ_G0017030
 protein coding gene Chr10:59249829-59277114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017665
 protein coding gene Chr10:61709884-61739794 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015356
 protein coding gene Chr10:54819873-54845541 (+)
CAST/EiJ MGP_CASTEiJ_G0016601
 protein coding gene Chr10:59211116-59238954 (+)
CBA/J MGP_CBAJ_G0017002
 protein coding gene Chr10:63942246-63971365 (+)
DBA/2J MGP_DBA2J_G0017107
 protein coding gene Chr10:57130013-57156587 (+)
FVB/NJ MGP_FVBNJ_G0017101
 protein coding gene Chr10:56366877-56392661 (+)
LP/J MGP_LPJ_G0017182
 protein coding gene Chr10:59970375-60000632 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017129
 protein coding gene Chr10:66423802-66450590 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017703
 protein coding gene Chr10:59145052-59172056 (+)
PWK/PhJ MGP_PWKPhJ_G0016384
 protein coding gene Chr10:56940234-56966665 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016167
 protein coding gene Chr10:58478211-58503716 (+)
WSB/EiJ MGP_WSBEiJ_G0016665
 protein coding gene Chr10:59069643-59096583 (+)



Homology
more
  • Human Ortholog
    VSIR, V-set immunoregulatory receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VSIR, V-set immunoregulatory receptor
  • Synonyms
    B7-H5, B7H5, C10orf54, DD1alpha, Dies1, GI24, PD-1H, PP2135, SISP1, VISTA
  • Links
    NCBI Gene ID: 64115
    neXtProt AC: NX_Q9H7M9
    UniProt: Q9H7M9

  • Chr Location
    10q22.1; chr10:71747556-71773520 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased leukocyte infiltration and T cell activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    24
  • cDNA Data
    64
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020101 Ensembl Gene Model | MGI Sequence Detail 25834 C57BL/6J ±  kb
    transcript ENSMUST00000020301 Ensembl | MGI Sequence Detail 4846 Not Applicable  
    polypeptide ENSMUSP00000020301 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000036955 V-type immunoglobulin domain-containing suppressor of T-cell activation
      (term hierarchy)
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR013106 Immunoglobulin V-set domain
      IPR042473 V-type immunoglobulin domain-containing suppressor of T-cell activation
    • GlyGen
      Q9D659 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 64
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 40
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:352241 Kim TK, et al., PD-1H/VISTA mediates immune evasion in acute myeloid leukemia. J Clin Invest. 2024 Feb 1;134(3):e164325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory