Hvcn1 MGI Mouse Gene Detail - MGI:1921346 - hydrogen voltage-gated channel 1

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Hvcn1 Gene Detail

Symbol

Hvcn1
Name

hydrogen voltage-gated channel 1
Synonyms

0610039P13Rik, BTS, mVSOP

Feature Type

protein coding gene
IDs

MGI:1921346
NCBI Gene: 74096
Alliance

gene page
Transcription Start Sites

29 TSS

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Sequence Map

Chr5:122344872-122380360 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.23 cM
Mapping Data

2 experiments

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SNPs within 2kb

1098 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1921346	protein coding gene	Chr5:122344867-122380360 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030044	protein coding gene	Chr5:125824512-125865415 (+)
A/J	MGP_AJ_G0030009	protein coding gene	Chr5:120619332-120656879 (+)
AKR/J	MGP_AKRJ_G0029945	protein coding gene	Chr5:124491948-124532401 (+)
BALB/cJ	MGP_BALBcJ_G0030020	protein coding gene	Chr5:121964930-122001397 (+)
C3H/HeJ	MGP_C3HHeJ_G0029737	protein coding gene	Chr5:125111901-125148425 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030473	protein coding gene	Chr5:130657572-130700577 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027699	protein coding gene	Chr5:115226470-115263301 (+)
CAST/EiJ	MGP_CASTEiJ_G0029146	protein coding gene	Chr5:124209289-124247843 (+)
CBA/J	MGP_CBAJ_G0029707	protein coding gene	Chr5:135781008-135833997 (+)
DBA/2J	MGP_DBA2J_G0029857	protein coding gene	Chr5:120675039-120710679 (+)
FVB/NJ	MGP_FVBNJ_G0029813	protein coding gene	Chr5:119657922-119702095 (+)
LP/J	MGP_LPJ_G0029946	protein coding gene	Chr5:126361026-126411612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029844	protein coding gene	Chr5:139550179-139592535 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030514	protein coding gene	Chr5:124086909-124129268 (+)
PWK/PhJ	MGP_PWKPhJ_G0028860	protein coding gene	Chr5:119440238-119478048 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028697	protein coding gene	Chr5:121788440-121827335 (+)
WSB/EiJ	MGP_WSBEiJ_G0029221	protein coding gene	Chr5:124750803-124792283 (+)

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Human Ortholog

HVCN1, hydrogen voltage gated channel 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HVCN1, hydrogen voltage gated channel 1
Synonyms

HV1, VSOP
Links

HGNC:28240

NCBI Gene ID: 84329

neXtProt AC: NX_Q96D96

UniProt: Q96D96
Chr Location

12q24.11; chr12:110627841-110704952 (-) GRCh38

MGI Vertebrate Homology

Hvcn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HVCN1
Gene Tree

Hvcn1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
48 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

22
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Hvcn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a gene trap allele lack neutrophil and macrophage voltage-gated proton pumps.

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All GO Annotations

40
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hvcn1

ZFIN hvcn1

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All Sequences

61
RefSeq

10
UniProt

4
CCDS

CCDS19644.1

Ensembl

ENSMUSG00000064267 (Evidence)
NCBI Gene

74096

Representative Sequences				Length	Strain/Species	Flank
	genomic	74096	NCBI Gene Model \| MGI Sequence Detail	35489	C57BL/6J	± kb
	transcript	NM_001042489	RefSeq \| MGI Sequence Detail	2790	C57BL/6
	polypeptide	Q3U2S8	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008846 voltage-gated hydrogen channel 1

(term hierarchy)
PDB

3VMX, 3VMY, 3VMZ, 3VN0, 3VYI, 3WKV
InterPro Domains

IPR005821 Ion transport domain

IPR027359 Voltage-dependent channel domain superfamily

IPR031846 Voltage-gated hydrogen channel 1

IPR031844 Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain

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All nucleic 11

cDNA 10

Other 1

Microarray probesets 3

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MGI:2140895

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Summaries

All 80

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 48
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:339454 Li Y, et al., Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury. Glia. 2023 Oct;71(10):2418-2436

TSS for Hvcn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48642	Chr5:122344855-122344892 (+)	2 bp
Tssr48643	Chr5:122347877-122347906 (+)	3,020 bp
Tssr48644	Chr5:122347911-122347977 (+)	3,072 bp
Tssr48645	Chr5:122347981-122347984 (+)	3,111 bp
Tssr48646	Chr5:122348033-122348046 (+)	3,168 bp
Tssr48647	Chr5:122348140-122348187 (+)	3,292 bp
Tssr48648	Chr5:122348346-122348358 (+)	3,480 bp
Tssr48649	Chr5:122348368-122348379 (+)	3,502 bp
Tssr48650	Chr5:122348391-122348416 (+)	3,532 bp
Tssr48651	Chr5:122348419-122348430 (+)	3,553 bp
Tssr48652	Chr5:122348694-122348698 (+)	3,824 bp
Tssr48653	Chr5:122357302-122357309 (+)	12,434 bp
Tssr48654	Chr5:122357891-122357918 (+)	13,033 bp
Tssr48655	Chr5:122362475-122362480 (+)	17,606 bp
Tssr48656	Chr5:122364777-122364797 (+)	19,915 bp
Tssr48657	Chr5:122364918-122364929 (+)	20,052 bp
Tssr48658	Chr5:122365191-122365203 (+)	20,325 bp
Tssr48659	Chr5:122369090-122369103 (+)	24,225 bp
Tssr48660	Chr5:122370323-122370345 (+)	25,462 bp
Tssr48661	Chr5:122370429-122370450 (+)	25,568 bp
Tssr48662	Chr5:122371475-122371499 (+)	26,615 bp
Tssr48663	Chr5:122371644-122371681 (+)	26,791 bp
Tssr48664	Chr5:122373463-122373479 (+)	28,599 bp
Tssr48665	Chr5:122378718-122378734 (+)	33,854 bp
Tssr48666	Chr5:122378788-122378820 (+)	33,932 bp
Tssr48667	Chr5:122378827-122378889 (+)	33,986 bp
Tssr48668	Chr5:122378995-122379076 (+)	34,164 bp
Tssr48669	Chr5:122379086-122379126 (+)	34,234 bp
Tssr48670	Chr5:122379220-122379239 (+)	34,358 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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