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F13a1 Gene Detail
Summary
  • Symbol
    F13a1
  • Name
    coagulation factor XIII, A1 subunit
  • Synonyms
    1200014I03Rik, Factor XIIIA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921395
    NCBI Gene: 74145
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:37051152-37234220 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4789 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921395
 protein coding gene Chr13:37051150-37234220 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020464
 protein coding gene Chr13:35104991-35297554 (-)
A/J MGP_AJ_G0020418
 protein coding gene Chr13:34047687-34224518 (-)
AKR/J MGP_AKRJ_G0020396
 protein coding gene Chr13:34898875-35093652 (-)
BALB/cJ MGP_BALBcJ_G0020414
 protein coding gene Chr13:34125795-34303744 (-)
C3H/HeJ MGP_C3HHeJ_G0020213
 protein coding gene Chr13:34737557-34933170 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020847
 protein coding gene Chr13:36270225-36462318 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018434
 protein coding gene Chr13:32240176-32411340 (-)
CAST/EiJ MGP_CASTEiJ_G0019728
 protein coding gene Chr13:34474484-34664433 (-)
CBA/J MGP_CBAJ_G0020174
 protein coding gene Chr13:37815592-38015562 (-)
DBA/2J MGP_DBA2J_G0020296
 protein coding gene Chr13:33565314-33740922 (-)
FVB/NJ MGP_FVBNJ_G0020275
 protein coding gene Chr13:33097477-33279310 (-)
LP/J MGP_LPJ_G0020371
 protein coding gene Chr13:35336559-35522923 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020305
 protein coding gene Chr13:37986358-38184407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020890
 protein coding gene Chr13:34472779-34667204 (-)
PWK/PhJ MGP_PWKPhJ_G0019483
 protein coding gene Chr13:33675785-33854755 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019314
 protein coding gene Chr13:33163806-33351854 (-)
WSB/EiJ MGP_WSBEiJ_G0019790
 protein coding gene Chr13:34837861-35022248 (-)



Homology
more
  • Human Ortholog
    F13A1, coagulation factor XIII A chain
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F13A1, coagulation factor XIII A chain
  • Synonyms
    F13A
  • Links
    NCBI Gene ID: 2162
    neXtProt AC: NX_P00488
    UniProt: P00488

  • Chr Location
    6p25.1; chr6:6144084-6321013 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with F13a1 mouse models; 7 with human F13A1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit bleeding symptoms, increased lethality, and impaired fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    130
  • cDNA Data
    66
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039109 Ensembl Gene Model | MGI Sequence Detail 183069 C57BL/6J ±  kb
    transcript ENSMUST00000037491 Ensembl | MGI Sequence Detail 3954 Not Applicable  
    polypeptide ENSMUSP00000048667 Ensembl | MGI Sequence Detail 732 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145250
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory