About   Help   FAQ
Sipa1l3 Gene Detail
Summary
  • Symbol
    Sipa1l3
  • Name
    signal-induced proliferation-associated 1 like 3
  • Synonyms
    2610511M17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921456
    NCBI Gene: 74206
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:29019797-29218066 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6089 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921456
 protein coding gene Chr7:29016687-29218694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031983
 protein coding gene Chr7:28244997-28448766 (-)
A/J MGP_AJ_G0031961
 protein coding gene Chr7:27493822-27694774 (-)
AKR/J MGP_AKRJ_G0031894
 protein coding gene Chr7:28213771-28424981 (-)
BALB/cJ MGP_BALBcJ_G0031968
 protein coding gene Chr7:27693063-27891997 (-)
C3H/HeJ MGP_C3HHeJ_G0031687
 protein coding gene Chr7:28612040-28823208 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032433
 protein coding gene Chr7:29142199-29356484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029483
 protein coding gene Chr7:28547200-28745647 (-)
CAST/EiJ MGP_CASTEiJ_G0031021
 protein coding gene Chr7:21879669-22093554 (-)
CBA/J MGP_CBAJ_G0031653
 protein coding gene Chr7:30514094-30736104 (-)
DBA/2J MGP_DBA2J_G0031805
 protein coding gene Chr7:27234768-27433398 (-)
FVB/NJ MGP_FVBNJ_G0031762
 protein coding gene Chr7:27352520-27556297 (-)
LP/J MGP_LPJ_G0031885
 protein coding gene Chr7:28544222-28753588 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031797
 protein coding gene Chr7:29877930-30081026 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032462
 protein coding gene Chr7:27700837-27908267 (-)
PWK/PhJ MGP_PWKPhJ_G0030747
 protein coding gene Chr7:22292158-22495328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030580
 protein coding gene Chr7:18710525-18924010 (-)
WSB/EiJ MGP_WSBEiJ_G0031131
 protein coding gene Chr7:28079838-28290682 (-)



Homology
more
  • Human Ortholog
    SIPA1L3, signal induced proliferation associated 1 like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIPA1L3, signal induced proliferation associated 1 like 3
  • Synonyms
    CTRCT45, SPAL3, SPAR3
  • Links
    NCBI Gene ID: 23094
    neXtProt AC: NX_O60292
    UniProt: O60292

  • Chr Location
    19q13.13-q13.2; chr19:37907208-38208369 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SIPA1L3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit small lenses, microphthalmia, cataracts, posterior iris synechia, and abnormal lens fiber morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    9
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030583 Ensembl Gene Model | MGI Sequence Detail 198270 C57BL/6J ±  kb
    transcript ENSMUST00000085809 Ensembl | MGI Sequence Detail 7713 Not Applicable  
    polypeptide ENSMUSP00000082965 Ensembl | MGI Sequence Detail 1776 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:254716 Walker LR, et al., A 16.7 kb deletion in Sipa1l3 is associated with juvenile cataract in mice. Mamm Genome. 2017 Dec;28(11-12):515-519
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory