Ubap2l MGI Mouse Gene Detail - MGI:1921633 - ubiquitin-associated protein 2-like

Symbol

Ubap2l
Name

ubiquitin-associated protein 2-like
Synonyms

3110083O19Rik, 4932431F02Rik, A430103N23Rik, mKIAA0144, NICE-4

Feature Type

protein coding gene
IDs

MGI:1921633
NCBI Gene: 74383
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr3:89907447-89959935 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.19 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

777 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921633	protein coding gene	Chr3:89906896-89959935 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027451	protein coding gene	Chr3:90261552-90315195 (-)
A/J	MGP_AJ_G0027415	protein coding gene	Chr3:87268521-87321563 (-)
AKR/J	MGP_AKRJ_G0027379	protein coding gene	Chr3:89402372-89456590 (-)
BALB/cJ	MGP_BALBcJ_G0027424	protein coding gene	Chr3:87231057-87283492 (-)
C3H/HeJ	MGP_C3HHeJ_G0027166	protein coding gene	Chr3:89582210-89635521 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027870	protein coding gene	Chr3:93647767-93706248 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025222	protein coding gene	Chr3:82761036-82819042 (-)
CAST/EiJ	MGP_CASTEiJ_G0026612	protein coding gene	Chr3:89951858-90005240 (-)
CBA/J	MGP_CBAJ_G0027140	protein coding gene	Chr3:96897351-96952223 (-)
DBA/2J	MGP_DBA2J_G0027278	protein coding gene	Chr3:86641916-86695319 (-)
FVB/NJ	MGP_FVBNJ_G0027246	protein coding gene	Chr3:84977234-85030548 (-)
LP/J	MGP_LPJ_G0027387	protein coding gene	Chr3:91333615-91386040 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027266	protein coding gene	Chr3:103075537-103130912 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027929	protein coding gene	Chr3:89147692-89202617 (-)
PWK/PhJ	MGP_PWKPhJ_G0026346	protein coding gene	Chr3:86531307-86585757 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026165	protein coding gene	Chr3:88324569-88379729 (-)
WSB/EiJ	MGP_WSBEiJ_G0026694	protein coding gene	Chr3:89548772-89601691 (-)

Human Ortholog

UBAP2L, ubiquitin associated protein 2 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBAP2L, ubiquitin associated protein 2 like
Synonyms

NEDLBF, NICE-4, NICE4
Links

HGNC:29877

NCBI Gene ID: 9898

neXtProt AC: NX_Q14157

UniProt: Q14157
Chr Location

1q21.3; chr1:154220172-154271510 (+) GRCh38

MGI Vertebrate Homology

Ubap2l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBAP2L
Gene Tree

Ubap2l

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

47
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Ubap2l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit decreased female body size and reduced female fertility.

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All GO Annotations

14
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

30
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubap2l

ZFIN ubap2l

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All Sequences

165
RefSeq

26
UniProt

15
CCDS

CCDS38498.1, CCDS50965.1, CCDS50966.1, CCDS79958.1, CCDS79959.1, CCDS79960.1

Ensembl

ENSMUSG00000042520 (Evidence)
NCBI Gene

74383

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042520	Ensembl Gene Model \| MGI Sequence Detail	52489	C57BL/6J	± kb
transcript	ENSMUST00000064639	Ensembl \| MGI Sequence Detail	4073	Not Applicable
polypeptide	ENSMUSP00000066138	Ensembl \| MGI Sequence Detail	1112	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000016960 ubiquitin-associated protein 2-like

(term hierarchy)
PDB

1WJ7
InterPro Domains

IPR051833 Transcription-coupled DNA damage response regulator

IPR009060 UBA-like superfamily

IPR022166 UBAP2/protein lingerer

IPR015940 Ubiquitin-associated domain
GlyGen

Q80X50 26 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (24 sites)

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All nucleic 31

cDNA 31

Microarray probesets 6

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MGI:1920486, MGI:1924440, MGI:2140046

Summaries

All 51

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 19
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ubap2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34191	Chr3:89959915-89959934 (-)	10 bp
Tssr34190	Chr3:89959770-89959828 (-)	136 bp
Tssr34189	Chr3:89959739-89959766 (-)	182 bp
Tssr34188	Chr3:89952342-89952351 (-)	7,588 bp
Tssr34187	Chr3:89928243-89928272 (-)	31,677 bp
Tssr34186	Chr3:89926539-89926551 (-)	33,390 bp
Tssr34185	Chr3:89926504-89926519 (-)	33,423 bp
Tssr34184	Chr3:89925749-89925787 (-)	34,167 bp
Tssr34183	Chr3:89924916-89924920 (-)	35,017 bp
Tssr34182	Chr3:89924126-89924138 (-)	35,803 bp
Tssr34181	Chr3:89921734-89921739 (-)	38,198 bp
Tssr34180	Chr3:89916595-89916613 (-)	43,331 bp
Tssr34179	Chr3:89909572-89909597 (-)	50,350 bp
Tssr34178	Chr3:89908101-89908111 (-)	51,829 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24