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Mlkl Gene Detail
Summary
  • Symbol
    Mlkl
  • Name
    mixed lineage kinase domain-like
  • Synonyms
    9130019I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921818
    NCBI Gene: 74568
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112038429-112064809 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    686 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921818
 protein coding gene Chr8:112037879-112065081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034138
 protein coding gene Chr8:114079908-114111361 (-)
A/J MGP_AJ_G0034118
 protein coding gene Chr8:109439745-109468289 (-)
AKR/J MGP_AKRJ_G0034045
 protein coding gene Chr8:112646169-112676375 (-)
BALB/cJ MGP_BALBcJ_G0034112
 protein coding gene Chr8:109618806-109648826 (-)
C3H/HeJ MGP_C3HHeJ_G0033823
 protein coding gene Chr8:113358464-113386653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034632
 protein coding gene Chr8:118075028-118101214 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031574
 protein coding gene Chr8:102408999-102437432 (-)
CAST/EiJ MGP_CASTEiJ_G0033150
 protein coding gene Chr8:112997054-113026687 (-)
CBA/J MGP_CBAJ_G0033796
 protein coding gene Chr8:122101514-122136479 (-)
DBA/2J MGP_DBA2J_G0033952
 protein coding gene Chr8:108727938-108754388 (-)
FVB/NJ MGP_FVBNJ_G0033895
 protein coding gene Chr8:107688547-107718616 (-)
LP/J MGP_LPJ_G0034042
 protein coding gene Chr8:114245400-114276004 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033942
 protein coding gene Chr8:124960561-124987930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034650
 protein coding gene Chr8:112624997-112653053 (-)
PWK/PhJ MGP_PWKPhJ_G0032852
 protein coding gene Chr8:108313235-108343005 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032692
 protein coding gene Chr8:111281570-111318802 (-)
WSB/EiJ MGP_WSBEiJ_G0033266
 protein coding gene Chr8:113301031-113329599 (-)



Homology
more
  • Human Ortholog
    MLKL, mixed lineage kinase domain like pseudokinase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLKL, mixed lineage kinase domain like pseudokinase
  • Synonyms
    hMLKL
  • Links
    NCBI Gene ID: 197259
    neXtProt AC: NX_Q8NB16
    UniProt: Q8NB16

  • Chr Location
    16q23.1; chr16:74671855-74700960 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 7 alleles in 7 genetic backgrounds
    13 phenotypes from multigenic genotypes
    146 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit imapired macrophage and mouse embryonic fibroblast necroptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    20
  • cDNA Data
    8
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000012519 Ensembl Gene Model | MGI Sequence Detail 26381 C57BL/6J ±  kb
    transcript ENSMUST00000056157 Ensembl | MGI Sequence Detail 2003 Not Applicable  
    polypeptide ENSMUSP00000055521 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029123 mixed lineage kinase domain-like protein
      (term hierarchy)
    • PDB
      4BTF, 4M68, 4M69
    • InterPro Domains
      IPR036537 Adaptor protein Cbl, N-terminal domain superfamily
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR051681 Serine/Threonine Kinases and Pseudokinases
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    • GlyGen
      Q9D2Y4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 206
      Developmental Gene Expression 16
      Gene Ontology 13
      Phenotypes 146
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353414 Shojaie L, et al., Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors. Cell Death Dis. 2024 Feb 14;15(2):140
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory