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Lrriq1 Gene Detail
Summary
  • Symbol
    Lrriq1
  • Name
    leucine-rich repeats and IQ motif containing 1
  • Synonyms
    4930503E15Rik, Gm1557, LOC380658
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922228
    NCBI Gene: 74978
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:102881892-103072183 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 53.65 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5606 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922228
 protein coding gene Chr10:102880238-103072236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017698
 protein coding gene Chr10:105082027-105286187 (-)
A/J MGP_AJ_G0017677
 protein coding gene Chr10:101223782-101409495 (-)
AKR/J MGP_AKRJ_G0017639
 protein coding gene Chr10:104189543-104378947 (-)
BALB/cJ MGP_BALBcJ_G0017641
 protein coding gene Chr10:101581744-101774013 (-)
C3H/HeJ MGP_C3HHeJ_G0017466
 protein coding gene Chr10:104202301-104399577 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018098
 protein coding gene Chr10:108757776-108953360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015777
 protein coding gene Chr10:96468832-96654017 (-)
CAST/EiJ MGP_CASTEiJ_G0017027
 protein coding gene Chr10:104283485-104490335 (-)
CBA/J MGP_CBAJ_G0017435
 protein coding gene Chr10:112899550-113124535 (-)
DBA/2J MGP_DBA2J_G0017540
 protein coding gene Chr10:100321463-100513221 (-)
FVB/NJ MGP_FVBNJ_G0017534
 protein coding gene Chr10:99398214-99591406 (-)
LP/J MGP_LPJ_G0017614
 protein coding gene Chr10:105687152-105881310 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017564
 protein coding gene Chr10:114745928-115023347 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018136
 protein coding gene Chr10:104114802-104313599 (-)
PWK/PhJ MGP_PWKPhJ_G0016809
 protein coding gene Chr10:100432839-100628587 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016599
 protein coding gene Chr10:102940191-103146574 (-)
WSB/EiJ MGP_WSBEiJ_G0017087
 protein coding gene Chr10:104178182-104398246 (-)



Homology
more
  • Human Ortholog
    LRRIQ1, leucine rich repeats and IQ motif containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRIQ1, leucine rich repeats and IQ motif containing 1
  • Links
    NCBI Gene ID: 84125
    neXtProt AC: NX_Q96JM4
    UniProt: Q96JM4

  • Chr Location
    12q21.31; chr12:85036314-85272805 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males exhibit reduced male infertility, with reduced sperm motility and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019892 Ensembl Gene Model | MGI Sequence Detail 190292 C57BL/6J ±  kb
    transcript ENSMUST00000166240 Ensembl | MGI Sequence Detail 5232 Not Applicable  
    polypeptide ENSMUSP00000131419 Ensembl | MGI Sequence Detail 1673 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032607 leucine-rich repeat and IQ domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR050576 Ciliary and flagellar integrity-associated protein
      IPR000048 IQ motif, EF-hand binding site
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050836 SDS22/Internalin LRR-containing
    • GlyGen
      Q0P5X1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2686403
    References
    more
    • Summaries
      All 29
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:338085 Fukutomi M, et al., Lrriq1 is an essential factor for fertility by suppressing apoptosis. J Assist Reprod Genet. 2022 Nov;39(11):2647-2657
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/24/2024
    MGI 6.24     		The Jackson Laboratory