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Ing5 Gene Detail
Summary
  • Symbol
    Ing5
  • Name
    inhibitor of growth family, member 5
  • Synonyms
    1700027H23Rik, 1810018M11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922816
    NCBI Gene: 66262
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93731687-93749823 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.34 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922816
 protein coding gene Chr1:93731648-93749823 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016350
 protein coding gene Chr1:95451913-95470030 (+)
A/J MGP_AJ_G0016331
 protein coding gene Chr1:92035410-92053685 (+)
AKR/J MGP_AKRJ_G0016292
 protein coding gene Chr1:94748810-94766888 (+)
BALB/cJ MGP_BALBcJ_G0016287
 protein coding gene Chr1:92216341-92234738 (+)
C3H/HeJ MGP_C3HHeJ_G0016116
 protein coding gene Chr1:95004961-95023181 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016746
 protein coding gene Chr1:99076810-99097188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014464
 protein coding gene Chr1:86276313-86294714 (+)
CAST/EiJ MGP_CASTEiJ_G0015699
 protein coding gene Chr1:94336241-94354433 (+)
CBA/J MGP_CBAJ_G0016090
 protein coding gene Chr1:102296908-102315043 (+)
DBA/2J MGP_DBA2J_G0016195
 protein coding gene Chr1:91235819-91254570 (+)
FVB/NJ MGP_FVBNJ_G0016194
 protein coding gene Chr1:90299098-90319537 (+)
LP/J MGP_LPJ_G0016266
 protein coding gene Chr1:96630155-96651878 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016219
 protein coding gene Chr1:105372943-105393685 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016785
 protein coding gene Chr1:94780036-94799578 (+)
PWK/PhJ MGP_PWKPhJ_G0015484
 protein coding gene Chr1:90665610-90684238 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015268
 protein coding gene Chr1:93717886-93736423 (+)
WSB/EiJ MGP_WSBEiJ_G0015759
 protein coding gene Chr1:94595481-94614649 (+)



Homology
more
  • Human Ortholog
    ING5, inhibitor of growth family member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING5, inhibitor of growth family member 5
  • Synonyms
    p28ING5
  • Links
    NCBI Gene ID: 84289
    neXtProt AC: NX_Q8WYH8
    UniProt: Q8WYH8

  • Chr Location
    2q37.3; chr2:241687020-241729478 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial preweaning lethality with impaired hematopoiesis in the fetal liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    149
  • cDNA Data
    63
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026283 Ensembl Gene Model | MGI Sequence Detail 18137 C57BL/6J ±  kb
    transcript ENSMUST00000027505 Ensembl | MGI Sequence Detail 4533 Not Applicable  
    polypeptide ENSMUSP00000027505 Ensembl | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 63
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1913512, MGI:2138176
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346139 Mah SYY, et al., ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory