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Nhej1 Gene Detail
Summary
  • Symbol
    Nhej1
  • Name
    non-homologous end joining factor 1
  • Synonyms
    1700029B21Rik, cernunnos, XLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922820
    NCBI Gene: 75570
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75006505-75101870 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.56 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1667 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922820
 protein coding gene Chr1:75006298-75101870 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016169
 protein coding gene Chr1:75585090-75683850 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016560
 protein coding gene Chr1:78526947-78638056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014281
 protein coding gene Chr1:68513951-68608337 (-)
CAST/EiJ MGP_CASTEiJ_G0015522
 protein coding gene Chr1:74639104-74740558 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0016015
 protein coding gene Chr1:71465936-71562334 (-)
LP/J MGP_LPJ_G0016084
 protein coding gene Chr1:76703418-76810009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016035
 protein coding gene Chr1:84457101-84552722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016607
 protein coding gene Chr1:75041854-75142931 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015087
 protein coding gene Chr1:74410433-74505444 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NHEJ1, non-homologous end joining factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NHEJ1, non-homologous end joining factor 1
  • Synonyms
    IMD124, MCOPCB13, XLF
  • Links
    NCBI Gene ID: 79840
    neXtProt AC: NX_Q9H9Q4
    UniProt: Q9H9Q4

  • Chr Location
    2q35; chr2:219069355-219160869 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NHEJ1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotypes from multigenic genotypes
    5 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null ES cells are sensitive to ionizing radiation and have defects in DNA repair. Lymphocyte numbers are modestly decreased in null homozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    20
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      56
    • RefSeq
      28
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75570 NCBI Gene Model | MGI Sequence Detail 95366 C57BL/6J ±  kb
    transcript NM_001432752 RefSeq | MGI Sequence Detail 2436 C57BL/6  
    polypeptide Q3KNJ2 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:332737 Vincendeau E, et al., SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nat Commun. 2022 Jun 28;13(1):3707
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory