About   Help   FAQ
Med25 Gene Detail
Summary
  • Symbol
    Med25
  • Name
    mediator complex subunit 25
  • Synonyms
    2610034E13Rik, 2610529E18Rik, ESTM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922863
    NCBI Gene: 75613
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44526189-44542136 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.95 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922863
 protein coding gene Chr7:44526189-44544771 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032184
 protein coding gene Chr7:45087406-45101637 (-)
A/J MGP_AJ_G0032163
 protein coding gene Chr7:44242930-44256677 (-)
AKR/J MGP_AKRJ_G0032099
 protein coding gene Chr7:45460251-45474845 (-)
BALB/cJ MGP_BALBcJ_G0032175
 protein coding gene Chr7:44242864-44255969 (-)
C3H/HeJ MGP_C3HHeJ_G0031891
 protein coding gene Chr7:45962254-45975755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032667
 protein coding gene Chr7:47353170-47365905 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029681
 protein coding gene Chr7:46813162-46826165 (-)
CAST/EiJ MGP_CASTEiJ_G0031219
 protein coding gene Chr7:37335049-37349133 (-)
CBA/J MGP_CBAJ_G0031855
 protein coding gene Chr7:48908354-48921179 (-)
DBA/2J MGP_DBA2J_G0032013
 protein coding gene Chr7:43913948-43926714 (-)
FVB/NJ MGP_FVBNJ_G0031964
 protein coding gene Chr7:43691338-43704641 (-)
LP/J MGP_LPJ_G0032091
 protein coding gene Chr7:45769863-45785498 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032001
 protein coding gene Chr7:47641110-47655055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032683
 protein coding gene Chr7:44684564-44699006 (-)
PWK/PhJ MGP_PWKPhJ_G0030942
 protein coding gene Chr7:37278324-37291876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030779
 protein coding gene Chr7:32683413-32698790 (-)
WSB/EiJ MGP_WSBEiJ_G0031336
 protein coding gene Chr7:45157677-45171175 (-)



Homology
more
  • Human Ortholog
    MED25, mediator complex subunit 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED25, mediator complex subunit 25
  • Synonyms
    ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758
  • Links
    NCBI Gene ID: 81857
    neXtProt AC: NX_Q71SY5
    UniProt: Q71SY5

  • Chr Location
    19q13.33; chr19:49818282-49840384 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    16
  • cDNA Data
    140
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002968 Ensembl Gene Model | MGI Sequence Detail 15948 C57BL/6J ±  kb
    transcript ENSMUST00000208253 Ensembl | MGI Sequence Detail 3693 Not Applicable  
    polypeptide ENSMUSP00000146405 Ensembl | MGI Sequence Detail 801 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000010297 mediator of RNA polymerase II transcription subunit 25
      (term hierarchy)
    • PDB
      6W1S, 8T1I
    • InterPro Domains
      IPR038196 Mediator complex subunit 25, PTOV domain superfamily
      IPR021394 Mediator complex, subunit Med25, PTOV domain
      IPR021397 Mediator complex, subunit Med25, synapsin 1
      IPR021419 Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain
      IPR040647 SPIN-DOC-like, zinc-finger
      IPR036465 von Willebrand factor A-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 140
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28123, MGI:104829
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory