Amotl1 MGI Mouse Gene Detail - MGI:1922973

Symbol

Amotl1
Name

angiomotin-like 1
Synonyms

2310010G08Rik, 2310067L22Rik, 4932416D09Rik, JEAP

Feature Type

protein coding gene
IDs

MGI:1922973
NCBI Gene: 75723
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr9:14453262-14556352 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 4.12 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

3224 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922973	protein coding gene	Chr9:14453262-14574408 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034351	protein coding gene	Chr9:11495700-11561783 (-)
A/J	MGP_AJ_G0034329	protein coding gene	Chr9:11447045-11513126 (-)
AKR/J	MGP_AKRJ_G0034257	protein coding gene	Chr9:11454209-11523976 (-)
BALB/cJ	MGP_BALBcJ_G0034323	protein coding gene	Chr9:11218749-11285233 (-)
C3H/HeJ	MGP_C3HHeJ_G0034034	protein coding gene	Chr9:11745132-11838923 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034845	protein coding gene	Chr9:11871910-11940772 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031783	protein coding gene	Chr9:10735202-10805849 (-)
CAST/EiJ	MGP_CASTEiJ_G0033361	protein coding gene	Chr9:11577206-11646015 (-)
CBA/J	MGP_CBAJ_G0034007	protein coding gene	Chr9:12424311-12520522 (-)
DBA/2J	MGP_DBA2J_G0034164	protein coding gene	Chr9:11321507-11412161 (-)
FVB/NJ	MGP_FVBNJ_G0034109	protein coding gene	Chr9:10911468-10977917 (-)
LP/J	MGP_LPJ_G0034250	protein coding gene	Chr9:11585358-11658686 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034153	protein coding gene	Chr9:13482813-13551318 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034864	protein coding gene	Chr9:11479890-11550118 (-)
PWK/PhJ	MGP_PWKPhJ_G0033067	protein coding gene	Chr9:11377387-11448598 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032903	protein coding gene	Chr9:11539916-11611168 (-)
WSB/EiJ	MGP_WSBEiJ_G0033477	protein coding gene	Chr9:11305887-11377952 (-)

Human Ortholog

AMOTL1, angiomotin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMOTL1, angiomotin like 1
Synonyms

JEAP
Links

HGNC:17811

NCBI Gene ID: 154810

neXtProt AC: NX_Q8IY63

UniProt: Q8IY63
Chr Location

11q21; chr11:94706431-94876748 (+) GRCh38

MGI Vertebrate Homology

Amotl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AMOTL1
Gene Tree

Amotl1

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Phenotype Summary

7 phenotypes from 4 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

Mice heterozygous for a missense mutation exhibit postnatal lethality while homozygotes exhibit prenatal and neonatal lethality with no apparent craniofacial or cardiovascular phenotypes.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

6
cDNA Data

141
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMOTL1

Xenbase amotl1

ZFIN amotl1

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All Sequences

65
RefSeq

18
UniProt

3
CCDS

CCDS40535.1

Ensembl

ENSMUSG00000013076 (Evidence)
NCBI Gene

75723

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013076	Ensembl Gene Model \| MGI Sequence Detail	103091	C57BL/6J	± kb
transcript	ENSMUST00000223132	Ensembl \| MGI Sequence Detail	3046	Not Applicable
polypeptide	ENSMUSP00000152834	Ensembl \| MGI Sequence Detail	1005	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003999 angiomotin-like protein 1

(term hierarchy)
InterPro Domains

IPR009114 Angiomotin

IPR024646 Angiomotin, C-terminal

IPR051747 Angiomotin-like regulatory protein

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All nucleic 142

cDNA 141

Primer pair 1

Microarray probesets 6

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MGI:1916817, MGI:1917651

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Amotl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88176	Chr9:14554851-14554867 (-)	1,493 bp
Tssr88175	Chr9:14554819-14554838 (-)	1,523 bp
Tssr88174	Chr9:14545587-14545620 (-)	10,748 bp
Tssr88173	Chr9:14545568-14545573 (-)	10,781 bp
Tssr88172	Chr9:14545531-14545536 (-)	10,818 bp
Tssr88171	Chr9:14526769-14526786 (-)	29,574 bp
Tssr88170	Chr9:14526741-14526751 (-)	29,606 bp
Tssr88169	Chr9:14526724-14526734 (-)	29,623 bp
Tssr88168	Chr9:14526714-14526721 (-)	29,634 bp
Tssr88167	Chr9:14526685-14526697 (-)	29,661 bp
Tssr88166	Chr9:14526593-14526605 (-)	29,753 bp
Tssr88165	Chr9:14526245-14526330 (-)	30,064 bp
Tssr88164	Chr9:14526189-14526202 (-)	30,156 bp
Tssr2783	Chr9:14526161-14526180 (-)	30,181 bp
Tssr88163	Chr9:14526122-14526133 (-)	30,224 bp
Tssr88162	Chr9:14526095-14526104 (-)	30,252 bp
Tssr88161	Chr9:14507815-14507831 (-)	48,529 bp
Tssr88160	Chr9:14485899-14485902 (-)	70,451 bp
Tssr88159	Chr9:14454870-14454908 (-)	101,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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