Lamp5 MGI Mouse Gene Detail - MGI:1923411 - lysosomal-associated membrane protein family, member 5

Symbol

Lamp5
Name

lysosomal-associated membrane protein family, member 5
Synonyms

3110035N03Rik, 6330527O06Rik, BAD-LAMP

Feature Type

protein coding gene
IDs

MGI:1923411
NCBI Gene: 76161
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:135894159-135911837 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 67.26 cM, cytoband G1
Mapping Data

2 experiments

SNPs within 2kb

434 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923411	protein coding gene	Chr2:135893945-135911837 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026556	protein coding gene	Chr2:139812925-139830504 (+)
A/J	MGP_AJ_G0026520	protein coding gene	Chr2:134129001-134146745 (+)
AKR/J	MGP_AKRJ_G0026494	protein coding gene	Chr2:137982236-137999845 (+)
BALB/cJ	MGP_BALBcJ_G0026532	protein coding gene	Chr2:134518070-134536457 (+)
C3H/HeJ	MGP_C3HHeJ_G0026275	protein coding gene	Chr2:138436974-138456969 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026977	protein coding gene	Chr2:144020089-144037697 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024354	protein coding gene	Chr2:128692067-128709819 (+)
CAST/EiJ	MGP_CASTEiJ_G0025736	protein coding gene	Chr2:138782780-138801749 (+)
CBA/J	MGP_CBAJ_G0026255	protein coding gene	Chr2:149389932-149407550 (+)
DBA/2J	MGP_DBA2J_G0026389	protein coding gene	Chr2:133507463-133525741 (+)
FVB/NJ	MGP_FVBNJ_G0026353	protein coding gene	Chr2:132096808-132115227 (+)
LP/J	MGP_LPJ_G0026493	protein coding gene	Chr2:139983072-140000655 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026373	protein coding gene	Chr2:153192017-153211615 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027032	protein coding gene	Chr2:137996251-138014272 (+)
PWK/PhJ	MGP_PWKPhJ_G0025472	protein coding gene	Chr2:133107555-133125317 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025274	protein coding gene	Chr2:137097897-137116678 (+)
WSB/EiJ	MGP_WSBEiJ_G0025810	protein coding gene	Chr2:138917478-138935724 (+)

Human Ortholog

LAMP5, lysosomal associated membrane protein family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMP5, lysosomal associated membrane protein family member 5
Synonyms

BAD-LAMP, BADLAMP, C20orf103, LAMP-5, UNC-46
Links

HGNC:16097

NCBI Gene ID: 24141

neXtProt AC: NX_Q9UJQ1

UniProt: Q9UJQ1
Chr Location

20p12.2; chr20:9514358-9530524 (+) GRCh38

MGI Vertebrate Homology

Lamp5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMP5
Gene Tree

Lamp5

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Lamp5
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show increased susceptibility to PTZ-induced seizures, distinct interneuron loss, dystrophic neurites, delayed habituation in the open field and neuronal network deficits.

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All GO Annotations

23
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

48
cDNA Data

8
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamp5

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All Sequences

46
RefSeq

9
UniProt

2
CCDS

CCDS16789.1

Ensembl

ENSMUSG00000027270 (Evidence)
NCBI Gene

76161

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027270	Ensembl Gene Model \| MGI Sequence Detail	17679	C57BL/6J	± kb
transcript	ENSMUST00000057503	Ensembl \| MGI Sequence Detail	1955	Not Applicable
polypeptide	ENSMUSP00000061180	Ensembl \| MGI Sequence Detail	280	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032148 lysosome-associated membrane glycoprotein 5

(term hierarchy)
InterPro Domains

IPR002000 Lysosome-associated membrane glycoprotein

IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains

IPR018134 Lysosome-associated membrane glycoprotein, conserved site
GlyGen

Q9D387 4 sites, 8 N-linked glycans (2 sites)

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1920368

Summaries

All 68

Developmental Gene Expression 11

Diseases 1

Gene Ontology 7

Phenotypes 33
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Lamp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20382	Chr2:135894100-135894119 (+)	-49 bp
Tssr20383	Chr2:135899631-135899643 (+)	5,478 bp
Tssr20384	Chr2:135899806-135899815 (+)	5,652 bp
Tssr20385	Chr2:135899875-135899901 (+)	5,729 bp
Tssr20386	Chr2:135900000-135900022 (+)	5,852 bp
Tssr667	Chr2:135900024-135900027 (+)	5,867 bp
Tssr20387	Chr2:135900058-135900069 (+)	5,905 bp
Tssr20388	Chr2:135900087-135900096 (+)	5,933 bp
Tssr20389	Chr2:135900127-135900132 (+)	5,971 bp
Tssr20390	Chr2:135900144-135900157 (+)	5,992 bp
Tssr20391	Chr2:135900165-135900183 (+)	6,015 bp
Tssr20392	Chr2:135900190-135900213 (+)	6,043 bp
Tssr20393	Chr2:135901695-135901724 (+)	7,551 bp
Tssr20394	Chr2:135902704-135902716 (+)	8,551 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24