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Fads1 Gene Detail
Summary
  • Symbol
    Fads1
  • Name
    fatty acid desaturase 1
  • Synonyms
    0710001O03Rik, A930006B21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923517
    NCBI Gene: 76267
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10160252-10174241 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923517
 protein coding gene Chr19:10160245-10174241 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024838
 protein coding gene Chr19:7506399-7520381 (+)
A/J MGP_AJ_G0024806
 protein coding gene Chr19:6989772-7003752 (+)
AKR/J MGP_AKRJ_G0024781
 protein coding gene Chr19:7270067-7284049 (+)
BALB/cJ MGP_BALBcJ_G0024806
 protein coding gene Chr19:7036277-7050257 (+)
C3H/HeJ MGP_C3HHeJ_G0024572
 protein coding gene Chr19:7156786-7170766 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025254
 protein coding gene Chr19:7851518-7865500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022681
 protein coding gene Chr19:7406587-7421619 (+)
CAST/EiJ MGP_CASTEiJ_G0024045
 protein coding gene Chr19:6817870-6831827 (+)
CBA/J MGP_CBAJ_G0024546
 protein coding gene Chr19:7900968-7914948 (+)
DBA/2J MGP_DBA2J_G0024673
 protein coding gene Chr19:7003442-7017422 (+)
FVB/NJ MGP_FVBNJ_G0024640
 protein coding gene Chr19:7041112-7055087 (+)
LP/J MGP_LPJ_G0024760
 protein coding gene Chr19:7482905-7496887 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024667
 protein coding gene Chr19:7807796-7821778 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025302
 protein coding gene Chr19:7292693-7306675 (+)
PWK/PhJ MGP_PWKPhJ_G0023790
 protein coding gene Chr19:6443636-6457725 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023595
 protein coding gene Chr19:6479281-6493274 (+)
WSB/EiJ MGP_WSBEiJ_G0024107
 protein coding gene Chr19:7174428-7188411 (+)



Homology
more
  • Human Ortholog
    FADS1, fatty acid desaturase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FADS1, fatty acid desaturase 1
  • Synonyms
    D5D, FADS6, FADSD5, LLCDL1, TU12
  • Links
    NCBI Gene ID: 3992
    neXtProt AC: NX_O60427
    UniProt: O60427

  • Chr Location
    11q12.2; chr11:61799627-61829318 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit arachidonic acid deficiency with premature lethality and altered prostaglandin levels. Heterozygous mice exhibit an intermediate phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    125
  • cDNA Data
    266
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010663 Ensembl Gene Model | MGI Sequence Detail 13990 C57BL/6J ±  kb
    transcript ENSMUST00000010807 Ensembl | MGI Sequence Detail 3460 Not Applicable  
    polypeptide ENSMUSP00000010807 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 266
      cDNA 266

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924436, MGI:2147505
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory