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Slc24a2 Gene Detail
Summary
  • Symbol
    Slc24a2
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
  • Synonyms
    6330417K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923626
    NCBI Gene: 76376
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86901361-87148714 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6767 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923626
 protein coding gene Chr4:86901361-87148780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028417
 protein coding gene Chr4:86770731-87034891 (-)
A/J MGP_AJ_G0028378
 protein coding gene Chr4:83802920-84057725 (-)
AKR/J MGP_AKRJ_G0028327
 protein coding gene Chr4:85863299-86121536 (-)
BALB/cJ MGP_BALBcJ_G0028398
 protein coding gene Chr4:83980816-84239818 (-)
C3H/HeJ MGP_C3HHeJ_G0028113
 protein coding gene Chr4:86546136-86816975 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028837
 protein coding gene Chr4:90121704-90382582 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026137
 protein coding gene Chr4:79845395-80083795 (-)
CAST/EiJ MGP_CASTEiJ_G0027554
 protein coding gene Chr4:84391391-84675940 (-)
CBA/J MGP_CBAJ_G0028082
 protein coding gene Chr4:92877224-93171533 (-)
DBA/2J MGP_DBA2J_G0028231
 protein coding gene Chr4:83540882-83788693 (-)
FVB/NJ MGP_FVBNJ_G0028197
 protein coding gene Chr4:82500008-82745458 (-)
LP/J MGP_LPJ_G0028331
 protein coding gene Chr4:87133643-87407248 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028226
 protein coding gene Chr4:97923517-98188545 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028874
 protein coding gene Chr4:85953121-86220955 (-)
PWK/PhJ MGP_PWKPhJ_G0027277
 protein coding gene Chr4:81868257-82120013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027102
 protein coding gene Chr4:83486732-83740790 (-)
WSB/EiJ MGP_WSBEiJ_G0027630
 protein coding gene Chr4:86163537-86441012 (-)



Homology
more
  • Human Ortholog
    SLC24A2, solute carrier family 24 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC24A2, solute carrier family 24 member 2
  • Synonyms
    NCKX2
  • Links
    NCBI Gene ID: 25769
    neXtProt AC: NX_Q9UI40
    UniProt: Q9UI40

  • Chr Location
    9p22.1-p21.3; chr9:19507452-20307892 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in loss of long term potentiation and an increase in long term depression and deficits in motor learning and spatial working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    14
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037996 Ensembl Gene Model | MGI Sequence Detail 247354 C57BL/6J ±  kb
transcript ENSMUST00000107158 Ensembl | MGI Sequence Detail 10499 Not Applicable  
polypeptide ENSMUSP00000102776 Ensembl | MGI Sequence Detail 711 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014999 sodium/potassium/calcium exchanger 2
    (term hierarchy)
  • InterPro Domains
    IPR044880 NCX, central ion-binding domain superfamily
    IPR004837 Sodium/calcium exchanger membrane region
    IPR004481 Sodium/potassium/calcium exchanger
  • GlyGen
    Q8BUN9 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917990, MGI:2140377
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:45794 Tsoi M, et al., Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain. J Biol Chem. 1998 Feb 13;273(7):4155-62
  • Latest
    J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory