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Ppp1r3g Gene Detail
Summary
  • Symbol
    Ppp1r3g
  • Name
    protein phosphatase 1, regulatory subunit 3G
  • Synonyms
    1600032L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923737
    NCBI Gene: 76487
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:36142822-36154371 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923737
 protein coding gene Chr13:36142816-36154371 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020460
 protein coding gene Chr13:34160180-34173246 (+)
A/J MGP_AJ_G0020414
 protein coding gene Chr13:33129371-33142511 (+)
AKR/J MGP_AKRJ_G0020392
 protein coding gene Chr13:33956076-33967608 (+)
BALB/cJ MGP_BALBcJ_G0020410
 protein coding gene Chr13:33194167-33208817 (+)
C3H/HeJ MGP_C3HHeJ_G0020209
 protein coding gene Chr13:33814493-33837225 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020843
 protein coding gene Chr13:35307065-35322018 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018430
 protein coding gene Chr13:31349239-31361119 (+)
CAST/EiJ MGP_CASTEiJ_G0019724
 protein coding gene Chr13:33535475-33548463 (+)
CBA/J MGP_CBAJ_G0020170
 protein coding gene Chr13:36819955-36838963 (+)
DBA/2J MGP_DBA2J_G0020292
 protein coding gene Chr13:32652531-32664535 (+)
FVB/NJ MGP_FVBNJ_G0020271
 protein coding gene Chr13:32194645-32207720 (+)
LP/J MGP_LPJ_G0020367
 protein coding gene Chr13:34390858-34402979 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020301
 protein coding gene Chr13:36975390-36989263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020886
 protein coding gene Chr13:33548766-33561100 (+)
PWK/PhJ MGP_PWKPhJ_G0019479
 protein coding gene Chr13:32764815-32777019 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019310
 protein coding gene Chr13:32257084-32268890 (+)
WSB/EiJ MGP_WSBEiJ_G0019786
 protein coding gene Chr13:33907566-33922284 (+)



Homology
more
  • Human Ortholog
    PPP1R3G, protein phosphatase 1 regulatory subunit 3G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R3G, protein phosphatase 1 regulatory subunit 3G
  • Links
    NCBI Gene ID: 648791
    neXtProt AC: NX_B7ZBB8
    UniProt: B7ZBB8

  • Chr Location
    6
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Under a high-fat diet, mice homozygous for a knock-out allele show decreased susceptibility to diet-induced obesity and hepatic steatosis along with a higher metabolic rate, increased food intake, and decreased glycogen levels in liver and adipose tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050423 Ensembl Gene Model | MGI Sequence Detail 11550 C57BL/6J ±  kb
    transcript ENSMUST00000225537 Ensembl | MGI Sequence Detail 2389 Not Applicable  
    polypeptide ENSMUSP00000153702 Ensembl | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 2
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:331156 Du J, et al., RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Nat Commun. 2021 Dec 3;12(1):7067
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory