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Clasp2 Gene Detail
Summary
  • Symbol
    Clasp2
  • Name
    CLIP associating protein 2
  • Synonyms
    1500004F14Rik, 8030404L10Rik, CLASP2, CLASP2alpha, CLASP2beta, CLASP2gamma, mKIAA0627
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923749
    NCBI Gene: 76499
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:113570541-113748750 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.06 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923749
 protein coding gene Chr9:113567776-113748765 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035380
 protein coding gene Chr9:116185113-116297547 (+)
A/J MGP_AJ_G0035361
 protein coding gene Chr9:111868949-111976450 (+)
AKR/J MGP_AKRJ_G0035292
 protein coding gene Chr9:114720348-114830085 (+)
BALB/cJ MGP_BALBcJ_G0035356
 protein coding gene Chr9:111690405-111801549 (+)
C3H/HeJ MGP_C3HHeJ_G0035064
 protein coding gene Chr9:115242663-115349489 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035877
 protein coding gene Chr9:119344714-119462348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032764
 protein coding gene Chr9:109009211-109129239 (+)
CAST/EiJ MGP_CASTEiJ_G0034370
 protein coding gene Chr9:115003602-115202828 (+)
CBA/J MGP_CBAJ_G0035031
 protein coding gene Chr9:123748713-123861427 (+)
DBA/2J MGP_DBA2J_G0035189
 protein coding gene Chr9:111337801-111446209 (+)
FVB/NJ MGP_FVBNJ_G0035136
 protein coding gene Chr9:110158657-110266337 (+)
LP/J MGP_LPJ_G0035269
 protein coding gene Chr9:116488683-116599893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035177
 protein coding gene Chr9:124996303-125110469 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035898
 protein coding gene Chr9:115112581-115233911 (+)
PWK/PhJ MGP_PWKPhJ_G0034075
 protein coding gene Chr9:111555901-111739194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033910
 protein coding gene Chr9:115102524-115288540 (+)
WSB/EiJ MGP_WSBEiJ_G0034490
 protein coding gene Chr9:114961818-115072974 (+)



Homology
more
  • Human Ortholog
    CLASP2, cytoplasmic linker associated protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLASP2, cytoplasmic linker associated protein 2
  • Links
    NCBI Gene ID: 23122
    neXtProt AC: NX_O75122
    UniProt: O75122

  • Chr Location
    3p22.3; chr3:33496245-33718356 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    21
  • cDNA Data
    95
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033392 Ensembl Gene Model | MGI Sequence Detail 178210 C57BL/6J ±  kb
transcript ENSMUST00000163895 Ensembl | MGI Sequence Detail 4112 Not Applicable  
polypeptide ENSMUSP00000128460 Ensembl | MGI Sequence Detail 1307 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 99
    cDNA 96
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:2143386
References
more
  • Summaries
    All 57
    Developmental Gene Expression 9
    Gene Ontology 13
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory