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Sdccag8 Gene Detail
Summary
  • Symbol
    Sdccag8
  • Name
    serologically defined colon cancer antigen 8
  • Synonyms
    2700048G21Rik, 5730470G24Rik, CCCAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924066
    NCBI Gene: 76816
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:176642226-176848003 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 82.66 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924066
 protein coding gene Chr1:176642226-176848004 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016846
 protein coding gene Chr1:182968092-183176800 (+)
A/J MGP_AJ_G0016825
 protein coding gene Chr1:175587272-175787827 (+)
AKR/J MGP_AKRJ_G0016791
 protein coding gene Chr1:180840412-181048624 (+)
BALB/cJ MGP_BALBcJ_G0016782
 protein coding gene Chr1:176115267-176315590 (+)
C3H/HeJ MGP_C3HHeJ_G0016608
 protein coding gene Chr1:181447545-181655363 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017247
 protein coding gene Chr1:189001762-189210553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014953
 protein coding gene Chr1:166879472-167073313 (+)
CAST/EiJ MGP_CASTEiJ_G0016189
 protein coding gene Chr1:180819559-181033711 (+)
CBA/J MGP_CBAJ_G0016581
 protein coding gene Chr1:195888812-196092097 (+)
DBA/2J MGP_DBA2J_G0016687
 protein coding gene Chr1:174449425-174653478 (+)
FVB/NJ MGP_FVBNJ_G0016684
 protein coding gene Chr1:172540006-172742589 (+)
LP/J MGP_LPJ_G0016762
 protein coding gene Chr1:184154952-184368488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016715
 protein coding gene Chr1:203114557-203323767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017283
 protein coding gene Chr1:180575685-180779176 (+)
PWK/PhJ MGP_PWKPhJ_G0015976
 protein coding gene Chr1:173527716-173731163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015753
 protein coding gene Chr1:179680011-179887091 (+)
WSB/EiJ MGP_WSBEiJ_G0016251
 protein coding gene Chr1:180807258-181013125 (+)



Homology
more
  • Human Ortholog
    SDCCAG8, SHH signaling and ciliogenesis regulator SDCCAG8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDCCAG8, SHH signaling and ciliogenesis regulator SDCCAG8
  • Synonyms
    BBS16, CCCAP, CCCAP SLSN7, hCCCAP, HSPC085, NPHP10, NY-CO-8, SLSN7
  • Links
    NCBI Gene ID: 10806
    neXtProt AC: NX_Q86SQ7
    UniProt: Q86SQ7

  • Chr Location
    1q43-q44; chr1:243256034-243500091 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Sdccag8 mouse models; 2 with human SDCCAG8 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show postnatal lethality, cleft palate, polydactyly, enlarged lateral ventricles and impaired neuronal migration. Homozygotes for a gene trap allele show late-onset nephronophthisis associated with renal cysts and fibrosis, and retinal degeneration leading to blindness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    18
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026504 Ensembl Gene Model | MGI Sequence Detail 205778 C57BL/6J ±  kb
    transcript ENSMUST00000027785 Ensembl | MGI Sequence Detail 2776 Not Applicable  
    polypeptide ENSMUSP00000027785 Ensembl | MGI Sequence Detail 717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917837
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:328191 Ren ZL, et al., Characterization of two novel knock-in mouse models of syndromic retinal ciliopathy carrying hypomorphic Sdccag8 mutations. Zool Res. 2022 May 18;43(3):442-456
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory