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Bicd2 Gene Detail
Summary
  • Symbol
    Bicd2
  • Name
    BICD cargo adaptor 2
  • Synonyms
    0610027D24Rik, 1110005D12Rik, mKIAA0699
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924145
    NCBI Gene: 76895
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:49495061-49540502 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 25.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    860 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924145
 protein coding gene Chr13:49495025-49540502 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020534
 protein coding gene Chr13:48314399-48359626 (+)
A/J MGP_AJ_G0020488
 protein coding gene Chr13:46594667-46640298 (+)
AKR/J MGP_AKRJ_G0020465
 protein coding gene Chr13:47909573-47958332 (+)
BALB/cJ MGP_BALBcJ_G0020484
 protein coding gene Chr13:46811961-46857168 (+)
C3H/HeJ MGP_C3HHeJ_G0020283
 protein coding gene Chr13:47733667-47778733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020917
 protein coding gene Chr13:49766528-49812107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018502
 protein coding gene Chr13:44573698-44618937 (+)
CAST/EiJ MGP_CASTEiJ_G0019798
 protein coding gene Chr13:47740493-47788287 (+)
CBA/J MGP_CBAJ_G0020244
 protein coding gene Chr13:51823241-51873174 (+)
DBA/2J MGP_DBA2J_G0020366
 protein coding gene Chr13:46122187-46168110 (+)
FVB/NJ MGP_FVBNJ_G0020345
 protein coding gene Chr13:45644272-45690419 (+)
LP/J MGP_LPJ_G0020441
 protein coding gene Chr13:48532555-48577929 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020374
 protein coding gene Chr13:51529083-51576704 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020960
 protein coding gene Chr13:47610900-47656677 (+)
PWK/PhJ MGP_PWKPhJ_G0019554
 protein coding gene Chr13:46304476-46350352 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019382
 protein coding gene Chr13:46317675-46366070 (+)
WSB/EiJ MGP_WSBEiJ_G0019860
 protein coding gene Chr13:47929211-47975186 (+)



Homology
more
  • Human Ortholog
    BICD2, BICD cargo adaptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BICD2, BICD cargo adaptor 2
  • Synonyms
    bA526D8.1, SMALED2, SMALED2A, SMALED2B
  • Links
    NCBI Gene ID: 23299
    neXtProt AC: NX_Q8TD16
    UniProt: Q8TD16

  • Chr Location
    9q22.31; chr9:92711363-92764833 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BICD2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    8 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show postnatal and premature death associated with progressive hydrocephalus, enlarged lateral ventricles, aqueductal stenosis, abnormal gait, disrupted laminar organization of the cerebral cortex and cerebellum, and impaired cerebellar granule cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    53
  • cDNA Data
    141
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037933 Ensembl Gene Model | MGI Sequence Detail 45442 C57BL/6J ±  kb
    transcript ENSMUST00000048544 Ensembl | MGI Sequence Detail 6309 Not Applicable  
    polypeptide ENSMUSP00000039394 Ensembl | MGI Sequence Detail 851 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 141

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1915741
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 15
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:301165 Rossor AM, et al., Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Acta Neuropathol Commun. 2020 Mar 17;8(1):34
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory