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Lbh Gene Detail
Summary
  • Symbol
    Lbh
  • Name
    limb-bud and heart
  • Synonyms
    1810009F10Rik, 6720416L16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925139
    NCBI Gene: 77889
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:73225300-73248941 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 44.73 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    629 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925139
 protein coding gene Chr17:73225300-73248942 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024017
 protein coding gene Chr17:75455978-75480595 (+)
A/J MGP_AJ_G0023975
 protein coding gene Chr17:73159365-73183941 (+)
AKR/J MGP_AKRJ_G0023944
 protein coding gene Chr17:74189851-74214353 (+)
BALB/cJ MGP_BALBcJ_G0023976
 protein coding gene Chr17:73074856-73098745 (+)
C3H/HeJ MGP_C3HHeJ_G0023740
 protein coding gene Chr17:75112730-75138869 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024422
 protein coding gene Chr17:78184912-78214106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021866
 protein coding gene Chr17:68867101-68890616 (+)
CAST/EiJ MGP_CASTEiJ_G0023221
 protein coding gene Chr17:75561695-75587638 (+)
CBA/J MGP_CBAJ_G0023715
 protein coding gene Chr17:81397962-81430132 (+)
DBA/2J MGP_DBA2J_G0023844
 protein coding gene Chr17:71789215-71815711 (+)
FVB/NJ MGP_FVBNJ_G0023810
 protein coding gene Chr17:71259264-71283503 (+)
LP/J MGP_LPJ_G0023926
 protein coding gene Chr17:76197182-76220807 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023838
 protein coding gene Chr17:81270513-81297982 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024466
 protein coding gene Chr17:74687769-74711824 (+)
PWK/PhJ MGP_PWKPhJ_G0022967
 protein coding gene Chr17:71122772-71148302 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022778
 protein coding gene Chr17:71358067-71381704 (+)
WSB/EiJ MGP_WSBEiJ_G0023288
 protein coding gene Chr17:75525816-75558940 (+)



Homology
more
  • Human Ortholog
    LBH, LBH regulator of WNT signaling pathway
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LBH, LBH regulator of WNT signaling pathway
  • Links
    NCBI Gene ID: 81606
    neXtProt AC: NX_Q53QV2
    UniProt: Q53QV2

  • Chr Location
    2p23.1; chr2:30231534-30323730 (+)  GRCh38
  • MGI Vertebrate Homology
    Lbh stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: LBH
  • Protein SuperFamily
    LBH
  • Gene Tree
    Lbh
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired mammary gland development and decreased litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    84
  • cDNA Data
    62
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77889 NCBI Gene Model | MGI Sequence Detail 23642 C57BL/6J ±  kb
    transcript NM_029999 RefSeq | MGI Sequence Detail 3068 C57BL/6  
    polypeptide Q9CX60 UniProt | EBI | MGI Sequence Detail 105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 63
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923995
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 10
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory